Dementia Research Institute

Our Dementia Research Institute houses state-of-the-art fluorescence microscopy systems.

Researchers can perform detailed studies of samples using spinning disc and laser-scanning confocals in addition to conducting large-scale screening approaches using a robot-assisted high-content screening platform.

Dedicated data-handling infrastructure and analysis software provides researchers with the tools to interrogate and analyse image data.

Learn more about the Dementia Research Institute

Equipment

Name	Make/Model	Details
High-content fluorescence imaging platform	Perkin Elmer Opera Phenix	Automated, high-content fluorescence imaging system with widefield and confocal capabilities. High-NA water immersion objectives give high resolution and maximise photon harvest. sCMOS cameras provide a large field of view and the system features environmental control for live cell imaging.
Laser scanning confocal	Leica SP8	Laser scanning confocal microscope for high quality fluorescence imaging. Hybrid detectors and prism-based spectral optics enhance sensitivity.
Spinning disc confocal	Zeiss Cell Observer SD.	A Yokagawa spinning disc head fitted to a Zeiss Examiner upright stand allows rapid and sensitive fluorescence imaging with optical sectioning and high image quality.
Single cell analysis system	TaKaRa ICELL8 cx Single-Cell System.	Single cell system for the rapid isolation and analysis of large numbers of single cells.
Low voltage transmission electron microscope	Delong Instruments LVEM25	Benchtop, easy to use low voltage transmission electron microscope
iPSC automated cell culture platform	Hamilton	Automated cell culture robot for the maintenance, splitting and differentiation of iPSC cultures
Lightsheet/SPIM fluorescence imaging system	Miltenyi Ultra Microscope II	Lightsheet/SPIM fluorescence imaging system with 4 imaging lasers. Particularly suited to the imaging of large (whole organ) samples, preferably cleared.
Fluorescence imaging plate reader	Molecular Devices FLIPR Penta	Fluorescence plate reader with liquid handling capabilities for compound or drug screening experiments with a fluorescence reporter.
Nanostring Spatial Transcriptomics platform	Nanostring GeoMX and nCounter	Spatial transcriptomics analyser plus nCounter analysis system for biomarker validation.