Dr Erik Mire
Research Fellow, Neuroscience & Mental Health Research Institute
- miree@cardiff.ac.uk
- Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
- Available for postgraduate supervision
Overview
My main interest are nicely exposed in the following declaration from UNICEF:
«The first 1,000 days of life - the time spanning roughly between conception and one’s second birthday - is a unique period of opportunity when the foundations of optimum health, growth, and neurodevelopment across the lifespan are established. Yet, too frequently in developing countries, poverty and its attendant condition, malnutrition, weaken this foundation, leading to earlier mortality and significant morbidities such as poor health, and more insidiously, substantial loss of neurodevelopmental potential »
I aim to understand how early life events, in particular related to diet, impact how our brain is shaped, with the idea that this will be crucial for its function later in life.
Biography
Publications
2021
- Galindo-Riera, N., Newbold, S. A., Sledziowska, M., Llinares-Benadero, C., Griffiths, J., Mire, E. and Martinez Garay, I. 2021. Cellular and behavioral characterization of Pcdh19 mutant mice: subtle molecular changes, increased exploratory behavior and an impact of social environment. eNeuro 8(4), article number: 510. (10.1523/ENEURO.0510-20.2021)
- Davis, J. and Mire, E. 2021. Maternal obesity and developmental programming of neuropsychiatric disorders: an inflammatory hypothesis. Brain and Neuroscience Advances 5, pp. 1-12. (10.1177/23982128211003484)
2018
- Mire, E., Hocine, M., Bazellieres, E., Jungas, T., Davy, A., Chauvet, S. and Mann, F. 2018. Developmental upregulation of ephrin-B1 silences sema3C/neuropilin-1 signaling during post-crossing navigation of corpus callosum axons. Current Biology 28(11), pp. 1768-1782. (10.1016/j.cub.2018.04.026)
- Decourtye, L. et al. 2018. Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation. PLoS ONE 13(2), pp. -., article number: e0193196. (10.1371/journal.pone.0193196)
2017
- Burk, K. et al. 2017. Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits. Nature Communications 8, article number: 14508. (10.1038/ncomms14508)
- Decourtye, L. et al. 2017. Correction: IGF-1 induces GHRH neuronal axon elongation during early postnatal life in mice (vol 12, e0170083, 2017). PLoS ONE 12(2), article number: e0172915. (10.1371/journal.pone.0172915)
- Decourtye, L. et al. 2017. IGF-1 induces GHRH neuronal axon elongation during early postnatal life in mice. PLoS ONE 12(1) (10.1371/journal.pone.0170083)
2015
- Deloulme, J. et al. 2015. Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth. Nature Communications 6, pp. -., article number: 7246. (10.1038/ncomms8246)
- Decourtye, L. et al. 2015. Leptin and IGF-I stimulate axon growth of hypothalmic GHRH neurons [Abstract]. Acta Physiologica 214, pp. 8., article number: CO-04-005.
- Decourtye, L. et al. 2015. Leptin and IGF-I stimulate axon growth of hypothalamic GHRH neurons. Acta Physiologica 214, pp. 8-8.
2014
- Bribian, A. et al. 2014. Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex. Nature Communications 5, article number: 4265. (10.1038/ncomms5265)
2012
- Mire, E. et al. 2012. Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth. Nature Neuroscience 15(8), pp. 1134-1143. (10.1038/nn.3160)
2011
- Bielle, F. et al. 2011. Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography. Current Biology 21(20), pp. 1748-1755. (10.1016/j.cub.2011.09.008)
2007
- Mire, E., Thomasset, N., Jakeman, L. and Rougon, G. 2007. Modulating Sema3A signal with a L1 mimetic peptide is not sufficient to promote motor recovery and axon regeneration after spinal cord injury. Molecular and Cellular Neuroscience 37(2), pp. 222-235. (10.1016/j.mcn.2007.09.009)
Projects
Current projects investigate how maternal obesity impacts brain development with a focus on diet and lipid metabolism.
We use state of the art approaches in imaging (lightsheet microscopy and brain clearing) and embryology (in utero electroporation), as well as mouse genetics, FACS, lipidomics, organotypic brain slice culture to study the cellular and molecular processes altered by maternal obesity in the offspring's brain.
The ultimate goal is to provide much needed information on signaling pathways and critical periods to help design preventive/corrective strategies for neuropsychiatirc disorders.
Collaborators
Professor Valerie O'Donnell, Cardiff University
Professor Paola Borri, Cardiff University
Professor William Griffiths, Swansea University
Funding
Research in the lab is supported by :
Wellcome Trust / Cardiff University ISSF Cross Disciplinary Award
Academy of Medical Science's Springboard Award
The Hodge Centre for Neuropsyciatric Immunology