Dr Enas Behiry
Wellcome Trust ISSF Fellow
- Henry Wellcome Building for Biomedical Research, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Overview
If you are a patient, thank you for reaching out to me after seeing the article about our research. It is at an early stage and although we are hopeful that these new cells will be therapeutically valuable, they have yet to be tested and approved for clinical trials. For more support please contact a cancer support group in your local area.
My research work focuses on investigating the chemical nature of cancer-specific ligands recognised by unconventional T-cells
Please see www.tcells.org for further details
Biography
B.Sc., (Chemistry / Biochemistry), Mansuora University, Egypt (2002-2007)
PhD, (Chemical Biology), School of Chemistry, Cardiff University, UK, (2008-2013, R. K. Allemann)
Research Associate, School of Chemistry, Cardiff University, UK, (2014-2018, R. K. Allemann)
Research Associate, School of Medicine, Division of Infection and Immunity, Cardiff University, UK, (2018, A. K. Sewell)
Wellcome Trust Research Fellow, School of Medicine, Division of Infection and Immunity, Cardiff University, UK, (2018)
Publications
2023
- Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
2022
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
2021
- Mezoughi, A. B. et al. 2021. The lysozyme inhibitor thionine acetate is also an inhibitor of the soluble lytic transglycosylase Slt35 from escherichia coli. Molecules 26(14), article number: 4189. (10.3390/molecules26144189)
2020
- El-Betany, A. M. M., Behiry, E. M., Gumbleton, M. and Harding, K. G. 2020. Humidified warmed CO2 treatment therapy strategies can save lives with mitigation and suppression of SARS-CoV-2 infection: an evidence review. Frontiers in Medicine 7, article number: 594295. (10.3389/fmed.2020.594295)
2018
- Behiry, E. M., Ruiz-Pernia, J. J., Luk, L., Tunon, I., Moliner, V. and Allemann, R. K. 2018. Isotope substitution of promiscuous alcohol dehydrogenase reveals the origin of substrate preference in the transition state. Angewandte Chemie International Edition 57(12), pp. 3128-3131. (10.1002/anie.201712826)
2017
- Hughes, R. L., Johnson, L. A., Behiry, E. M., Loveridge, E. J. and Allemann, R. K. 2017. A rapid analysis of variations in conformational behavior during dihydrofolate reductase catalysis. Biochemistry 56(15), pp. 2126-2133. (10.1021/acs.biochem.7b00045)
2016
- Ruiz-Pernía, J. J., Behiry, E., Luk, L. Y. P., Loveridge, E. J., Tuñón, I., Moliner, V. and Allemann, R. K. 2016. Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7(5), pp. 3248-3255. (10.1039/C5SC04209G)
2014
- Behiry, E. M., Luk, L. Y. P., Matthews, S. M., Loveridge, E. J. and Allemann, R. K. 2014. Role of the occluded conformation in bacterial dihydrofolate reductases. Biochemistry 53(29), pp. 4761-4768. (10.1021/bi500507v)
- Behiry, E. M., Evans, R. M., Guo, J. N., Loveridge, E. J. and Allemann, R. K. 2014. Loop Interactions during Catalysis by Dihydrofolate Reductase from Moritella profunda. Biochemistry 53(29), pp. 4769-4774. (10.1021/bi500508z)
2013
- Behiry, E. M. 2013. Dihydrofolate reductase and the physical basis of enzyme catalysis. PhD Thesis, Cardiff University.
2012
- Loveridge, E. J., Behiry, E. M., Guo, J. N. and Allemann, R. K. 2012. Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis. Nature Chemistry 4(4), pp. 292-297. (10.1038/nchem.1296)
2011
- Loveridge, E. J. et al. 2011. The role of large-scale motions in catalysis by dihydrofolate reductase. Journal of the American Chemical Society 133(50), pp. 20561-20570. (10.1021/ja208844j)
2010
- Evans, R. M., Behiry, E. M., Tey, L., Guo, J., Loveridge, E. J. and Allemann, R. K. 2010. Catalysis by Dihydrofolate Reductase from the Psychropiezophile Moritella profunda. ChemBioChem 11(14), pp. 2010-2017. (10.1002/cbic.201000341)
2009
- Loveridge, E. J., Behiry, E. M., Swanwick, R. S. and Allemann, R. K. 2009. Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases. Journal of the American Chemical Society 131(20), pp. 6926-6927. (10.1021/ja901441k)