Dr Patrick Van Eijk
Research Associate
- vaneijkp1@cardiff.ac.uk
- +44 (0)2920 687331
- 1F.14, Cancer Genetics Building, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Overview
Experienced Associate Researcher with a demonstrated history of establishing and working with NGS-based methods both in the wet-lab and bioinformatic analysis.
Biography
Education
- 2005: BSc. Life Science & Technology, Leiden University, the Netherlands
- 2007: MSc. Functional Genomics (cum laude), Leiden University, the Netherlands
Carreer overview
- 2020-Present: Co-founder & CTO of Broken String Biosciences Ltd
- 2014-Present: Reseach Associate, Prof. Simon Reed, School of Medicine, Cardiff University
- 2012: Visiting Scholar, Prof. Simon Reed, School of Medicine, Cardiff University
- 2012: PhD. Molecular Genetics, Prof. Dr. Jaap Brouwer, Yeast Genetics group, Leiden University, the Netherlands
PhD Thesis: Nucleotide Excision Repair in Yeast
Honours and awards
- 2017 FEBS YTF grant - young investigator travel fund: Bursary for attending the 2017 NER-ICL Workshop in Smolence, Slovakia.
Academic positions
- 2012: Visiting Scholar, Prof. Simon Reed, School of Medicine, Cardiff University
- 2012: PhD. Molecular Genetics, Prof. Dr. Jaap Brouwer, Yeast Genetics group, Leiden University, the Netherlands
PhD Thesis: Nucleotide Excision Repair in Yeast
Speaking engagements
- 2017 FEBS NER-ICL Workshop, Smolenice, Slovakia (poster presentation)
- 2016 Genome Stability Network UK meeting, Robertson College, Cambridge, UK (presented)
- 2014 Genome Stability Network UK meeting, Robertson College, Cambridge, UK (Invited speaker)
- 2008 Genome Stability Network UK meeting, Wellcome Trust, Hinxton, UK (presented)
- 2007 Medisch-Genetisch Centrum Zuid-West Nederland, DNA repair meeting, Erasmus MC, Rotterdam, the Netherlands (presented)
Committees and reviewing
- 2010 - 2009: MCG PhD Workshop committee: Organized the MGC PhD workshop 2010, Cologne, Germany
Publications
2024
- Mackay, H. L. et al. 2024. USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication. Nature Communications 15, article number: 8102. (10.1038/s41467-024-52250-4)
2023
- Newton, M. D. et al. 2023. Negative DNA supercoiling induces genome-wide Cas9 off-target activity. Molecular Cell 83(19), pp. 3533-3545.e5. (10.1016/j.molcel.2023.09.008)
- Yancoskie, M. N., Maritz, C., van Eijk, P., Reed, S. H. and Naegeli, H. 2023. To incise or not and where: SET-domain methyltransferases know. Trends in Biochemical Sciences 48(4), pp. 321-330. (10.1016/j.tibs.2022.10.003)
2022
- Murat, P., Perez, C., Crisp, A., van Eijk, P., Reed, S. H., Guilbaud, G. and Sale, J. E. 2022. DNA replication initiation shapes the mutational landscape and expression of the human genome. Science Advances 8(45) (10.1126/sciadv.add3686)
- Dobbs, F. M., van Eijk, P., Fellows, M. D., Loiacono, L., Nitsch, R. and Reed, S. H. 2022. Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq. Nature Communications 13, article number: 3989. (10.1038/s41467-022-31702-9)
2017
- Van Eijk, P., Teng, Y., Bennet, M. R., Evans, K., Powell, J. R., Webster, R. and Reed, S. 2017. Integrated microarray-based tools for detection of genomic DNA damage and repair mechanisms. In: Muzi-Falconi, M. and Brown, G. W. eds. Genome Instability. Methods in Molecular Biology., Vol. 1672. New York, NY: Humana Press, pp. 77., (10.1007/978-1-4939-7306-4_7)
2016
- Yu, S. et al. 2016. Global genome nucleotide excision repair is organized into domains that promote efficient DNA repair in chromatin. Genome Research 26, pp. 1376-1387. (10.1101/gr.209106.116)
2015
- Waters, R., van Eijk, P. and Reed, S. 2015. Histone modification and chromatin remodeling during NER. DNA Repair 36, pp. 105-113. (10.1016/j.dnarep.2015.09.013)
- Zhou, Z. et al. 2015. UV induced ubiquitination of the yeast Rad4–Rad23 complex promotes survival by regulating cellular dNTP pools. Nucleic Acids Research 43(15), pp. 7360-7370. (10.1093/nar/gkv680)
2008
- den Dulk, B., van Eijk, P., de Ruijter, M., Brandsma, J. A. and Brouwer, J. 2008. The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. DNA Repair 7(6), pp. 858-868. (10.1016/j.dnarep.2008.02.004)
Teaching
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2009 - 2007: Laboratory supervisor, Leiden Institute of Chemistry, Leiden University. Supervised undergraduate laboratory courses for groups of 24-30 students in:
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2009-2007: Gene-technology
- 2008-2007: Biochemistry
My research interests cover basic research on nucleotide excision repair (NER) and the mechanisms involved in the chromatin remodelling required during the different stages of repair. In September 2014 I joined the Reed lab, as a research associate, to study the organisation and mechanisms that underpin chromatin remodelling elicited before, during and after DNA repair by the NER pathway.
Supervision
Past projects
- Co-Supervisor for Shuvro Prokash Nandi
- Co-Supervisor for Hamed Hamed
- Co-Supervisor for Wenbin Wang
