Dr Josephine Haddon
Research Associate, Neuroscience and Mental Health Innovation Institute
- haddonje2@cardiff.ac.uk
- +44 29 2067 0569
- 3.28 - Desk 40, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Overview
I am interested in the role that contextual or environmental cues play in the control of both goal-directed and reflexive behaviours. The contextual control of behaviour has been implicated in a wide variety of situations from drug addiction to the formation of episodic memories. My focus is on the neural and psychological mechanisms underlying the contextual modulation of behaviour, with particular emphasis on the involvement of the prefrontal cortex and hippocampal formation. In addition, I am also interested in how dysfunction to contextual processes may contribute to neuropsychological disorders such as schizophrenia.
Biography
Publications
2024
- Haddon, J. E. et al. 2024. Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility. Translational Psychiatry 14(1), article number: 256. (10.1038/s41398-024-02969-x)
- George, D. N., Haddon, J. E. and Griffiths, O. 2024. Absence of differential protection from extinction in human causal learning.. Journal of Experimental Psychology: Animal Learning and Cognition (10.1037/xan0000380)
2023
- George, D. N., Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2, article number: kvad003. (10.1093/oons/kvad003)
2021
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47(1), pp. 48-62. (10.1037/xan0000266)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
2014
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, S. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67(5), pp. 918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D., Hindley, E. L., Haddon, J. E., Vann, S. D. and Aggleton, J. P. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21(2), pp. 90-97. (10.1101/lm.032136.113)
2013
- Cohen, S. R., Haddon, J. E., George, D. N. and Honey, R. C. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39(1), pp. 14-23. (10.1037/a0030594)
2011
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, A. S. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64(1), pp. 1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199, pp. 205-212. (10.1016/j.neuroscience.2011.09.065)
2008
- Haddon, J. E., George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61(9), pp. 1307-1320. (10.1080/17470210701515819)
2007
- Marquis, J., Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25(2), pp. 559-566. (10.1111/j.1460-9568.2006.05295.x)
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104(1), pp. 250-269. (10.1196/annals.1390.000)
2006
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26(11), pp. 2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin(54), pp. 18-20.
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19(8), pp. 1192-1202. (10.1016/j.neunet.2006.04.004)
2005
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84(3), pp. 485-504. (10.1901/jeab.2005.81-04)
- Nov 2006 - Present: BSRC - Project title: “Actions and habits: the relation between cognitive control and behavioural autonomy”
- Aug 2004 - Nov 2006: NARSAD - Project title: “Cue and response conflict: hippocampal and prefrontal contributions in schizophrenia”