Dr Terence Davis

2023

• Alimbetov, D., Umbayev, B., Tsoy, A., Begimbetova, D., Davis, T., Kipling, D. and Askarova, S. 2023. Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment. BMC Cancer 23(1), article number: 895. (10.1186/s12885-023-11319-x)

2022

• Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11(8), pp. 861-875. (10.1093/stcltm/szac037)

2019

• Davis, T. 2019. Premature ageing in Werner syndrome - A central role for genomic instability induced-cellular senescence via p38 MAPK activation. In: Bernhardt, L. V. ed. Advances in Medicine and Biology: Volume 143. New York: Nova Science, pp. 141-199.

2018

• Umbayev, B. et al. 2018. Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells. Biogerontology 19(3-4), pp. 287-301. (10.1007/s10522-018-9757-5)
• Alimbetov, D., Askarova, S., Umbayev, B., Davis, T. and Kipling, D. 2018. Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells. International Journal of Molecular Sciences 19(6), pp. 1690. (10.3390/ijms19061690)

2016

• Davis, T., Brook, A. J. C., Rokicki, M. J., Bagley, M. and Kipling, D. G. 2016. Evaluating the role of p38 MAPK in the accelerated cell senescence of Werner syndrome fibroblasts. Pharmaceuticals 9(2), article number: 23. (10.3390/ph9020023)
• Alimbetov, D. et al. 2016. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 17, article number: 305. (10.1007/s10522-015-9610-z)
• Bagley, M. C. et al. 2016. The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells. Organic & Biomolecular Chemistry 14(3), pp. 947-956. (10.1039/C5OB02229K)

2015

• Bagley, M., Baashen, M., Chuckowree, I., Dwyer, J., Kipling, D. G. and Davis, T. 2015. Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner Syndrome Cells. Pharmaceuticals 8(2), pp. 257-276. (10.3390/ph8020257)
• Davis, T., Tivey, H. S., Brook, A. J. and Kipling, D. 2015. Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence. Biogerontology 16(1), pp. 43-51. (10.1007/s10522-014-9530-3)

2014

• Cox, L. S. et al. 2014. Understanding ageing: biological and social constructions. In: Walker, A. ed. The New Science of Ageing. Bristol: Policy Press
• Davis, T. 2014. Progeroid syndromes: role of accelerated fibroblast senescence and p38 activation. In: Hayat, M. A. ed. Tumor Dormancy and Cellular Quiescence and Senescence, Volume 3: Aging, Cancer, and Noncancer Pathologies. Berlin: Springer Verlag, pp. 25-39., (10.1007/978-94-017-9325-4_3)
• Mark, B., Mohammed, B., Jessica, D., Pierre, M., Kipling, D. G. and Davis, T. 2014. Microwave-assisted Synthesis of Inhibitors of MK2 for Targeting p38 MAP Kinase Signalling in Werner Syndrome Cells. In: John, S. and Mark, B. eds. Microwaves in Drug Discovery and Development: Recent Advances. London: Future Medicine Ltd, pp. 86-104., (10.4155/fseb2013.13.130)

2013

• Bagley, M. C., Baashen, M., Paddock, V. L., Kipling, D. G. and Davis, T. 2013. Regiocontrolled synthesis of 3- and 5-aminopyrazoles, pyrazolo[3,4-d]pyrimidines, pyrazolo[3,4-b]pyridines and pyrazolo[3,4-b]quinolinones as MAPK inhibitors. Tetrahedron 69(39), pp. 8429-8438. (10.1016/j.tet.2013.07.055)
• Tivey, H. S. E., Brook, A. J. C., Rokicki, M. J., Kipling, D. G. and Davis, T. 2013. p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes. Biogerontology 14(1), pp. 47-62. (10.1007/s10522-012-9407-2)
• Davis, T., Rokicki, M. J., Bagley, M. C. and Kipling, D. G. 2013. The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome. Chemistry Central Journal 7, article number: 18. (10.1186/1752-153X-7-18)
• Davis, T., Tivey, H., Brook, A. J. C., Grimstead, J. W., Rokicki, M. J. and Kipling, D. G. 2013. Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund-Thomson syndrome. AGE 35(5), pp. 1767-1783. (10.1007/s11357-012-9476-9)
• Tivey, H. S. E., Rokicki, M. J., Barnacle, J. R., Rogers, M. J., Bagley, M. C., Kipling, D. G. and Davis, T. 2013. Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 68(9), pp. 1001-1009. (10.1093/gerona/gls336)

2011

• Davis, T., Dix, M. C., Rokicki, M. J., Brook, A. J. C., Widdowson, C. S., Kipling, D. G. and Bagley, M. C. 2011. Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors. Chemistry Central Journal 5(1), pp. 83-88. (10.1186/1752-153X-5-83)
• Bagley, M. C., Davis, T., Latimer, J. E. and Kipling, D. G. 2011. The contribution of biogerontology to quality ageing. Quality in Ageing and Older Adults 12(1), pp. 26-32. (10.5042/qiaoa.2011.0142)
• Latimer, J. E., Davis, T., Bagley, M. C. and Kipling, D. G. 2011. Ageing science, health care and social inclusion of older people. Quality in Ageing and Older Adults 12(1), pp. 11-16. (10.5042/qiaoa.2011.0140)
• Faragher, R. G. A., Burton, D. G. A., Majecha, P., Fong, N. S. Y., Davis, T., Sheerin, A. and Ostler, E. L. 2011. Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts. AGE 33(4), pp. 555-564. (10.1007/s11357-010-9201-5)

2010

• Bagley, M. C., Davis, T., Dix, M., Fusillo, V., Pigeaux, M., Rokicki, M. J. and Kipling, D. G. 2010. Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome. Future Medicinal Chemistry 2(9), pp. 1417-1427. (10.4155/fmc.10.217)
• Bagley, M. C., Davis, T., Murziani, P. G. S., Widdowson, C. and Kipling, D. G. 2010. Use of p38 MAPK inhibitors for the treatment of Werner Syndrome. Pharmaceuticals 3(6), pp. 1842-1872. (10.3390/ph3061842)
• Bagley, M. C., Davis, T., Dix, M. C., Murziani, P. G. S., Rokicki, M. J. and Kipling, D. G. 2010. Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells. Future Medicinal Chemistry 2(2), pp. 203-213. (10.4155/fmc.09.160)
• Bagley, M. C., Davis, T., Rokicki, M. J., Widdowson, C. S. and Kipling, D. G. 2010. Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome. Future Medicinal Chemistry 2(2), pp. 193-201. (10.4155/fmc.09.163)
• Davis, T., Bachler, M. A., Wyllie, F. S., Bagley, M. C. and Kipling, D. 2010. Evaluating the role of p38 MAP kinase in growth of Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1197(1), pp. 45-48. (10.1111/j.1749-6632.2010.05195.x)

2009

• Davis, T., Tivey, H. S. E. and Kipling, D. 2009. Telomere dynamics and biology in human progeroid syndromes. In: Mancini, L. ed. Telomeres: Function, Shortening and Lengthening. New York: Nova Science Publishers, Inc., pp. 1-75.
• Davis, T. and Kipling, D. G. 2009. Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of Ataxia Telangiectasia and Werner syndrome fibroblasts. Biogerontology 10(3), pp. 253-266. (10.1007/s10522-008-9179-x)
• Bagley, M. C., Davis, T., Dix, M. C., Fusillo, V., Pigeaux, M., Rokicki, M. J. and Kipling, D. G. 2009. Microwave-assisted Ullmann C-S bond formation: synthesis of the P38 alpha MAPK clinical candidate VX-745. Journal of Organic Chemistry 74(21), pp. 8336-8342. (10.1021/jo9017155)

2008

• Bagley, M. C., Davis, T., Dix, M. C., Murziani, P. G. S., Rokicki, M. J. and Kipling, D. G. 2008. Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 18(13), pp. 3745-3748. (10.1016/j.bmcl.2008.05.037)

2007

• Bagley, M. C., Davis, T., Dix, M., Rokicki, M. J. and Kipling, D. G. 2007. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Biorganic and Medicinal Chemistry Letters 17(18), pp. 5107-5110. (10.1016/j.bmcl.2007.07.016)
• Davis, T., Wyllie, F. S., Rokicki, M. J., Bagley, M. C. and Kipling, D. G. 2007. The Role of Cellular Senescence in Werner Syndrome: Toward Therapeutic Intervention in Human Premature Aging. Annals of the New York Academy of Sciences 1100, pp. 455-469. (10.1196/annals.1395.051)
• Davis, T. et al. 2007. Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38 alpha(MAPK) inhibitors in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 17(24), pp. 6832-6835. (10.1016/j.bmcl.2007.10.036)
• Davis, T. and Kipling, D. G. 2007. Werner syndrome, telomeres, and stress signaling: implications for future therapies?. In: Rudolph, K. L. ed. Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. Springer, pp. 285-308.

2006

• Bagley, M. C., Davis, T., Dix, M. C., Widdowson, C. S. and Kipling, D. G. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38α inhibitor BIRB 796 for study into accelerated cell ageing. Organic & Biomolecular Chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
• Bagley, M. C., Davis, T., Dix, M. C., Widdowson, C. S. and Kipling, D. G. 2006. Microwave-assisted synthesis of N-pyrazole ureas and the p38 inhibitor BIRB 796 for study into accelerated cell ageing. Organic & biomolecular chemistry 4(22), pp. 4158-4164. (10.1039/b611493h)
• Davis, T. and Kipling, D. G. 2006. Werner Syndrome as an example of inflamm-aging: Possible therapeutic opportunities for a progeroid syndrome?. Rejuvenation Research 9(3), pp. 402-407. (10.1089/rej.2006.9.402)
• Davis, T., Haughton, M. F., Jones, C. J. and Kipling, D. G. 2006. Prevention of accelerated cell aging in the Werner syndrome. Annals of the New York Academy of Sciences 1067(1), pp. 243-247. (10.1196/annals.1354.031)

2005

• Davis, T. and Kipling, D. G. 2005. Telomeres and telomerase biology in vertebrates: Progress towards a non-human model for replicative senescence and ageing. Biogerontology 6(6), pp. 371-385. (10.1007/s10522-005-4901-4)
• Davis, T., Baird, D. M., Haughton, M. F., Jones, C. J. and Kipling, D. G. 2005. Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor. The Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 60(11), pp. 1386-93.
• Davis, T., Skinner, J. W., Faragher, R. G. A., Jones, C. J. and Kipling, D. G. 2005. Replicative senescence in sheep fibroblasts is a p53 dependent process. Experimental Gerontology 40(1-2), pp. 17-26. (10.1016/j.exger.2004.09.004)

2004

• Kipling, D. G., Davis, T., Ostler, E. L. and Faragher, R. G. A. 2004. What can progeroid syndromes tell us about human aging?. Science 305(5689), pp. 1426-1431. (10.1126/science.1102587)
• Baird, D. M., Davis, T., Rowson, J. M., Jones, C. J. and Kipling, D. G. 2004. Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells. Human Molecular Genetics 13(14), pp. 1515-1524. (10.1093/hmg/ddh159)
• Davis, T., Faragher, R. G. A., Jones, C. J. and Kipling, D. G. 2004. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. Annals of the New York Academy of Sciences 1019(1), pp. 274-277. (10.1196/annals.1297.046)

2003

• Davis, T. 2003. Use of cross-species genome comparison to deduce possible importance of the various D. melanogaster fruitless transcripts: a putative vital function for the type C transcription factor?. Drosophila Information Service 86, pp. 133-136.
• Davis, T. 2003. The genes of the elbow-no-ocelli genetic complex in D. melanogaster. Drosophila Information Service 86, pp. 126-128.
• Davis, T. et al. 2003. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms. Journal of Cell Science (JCS) 116(7), pp. 1349-57. (10.1242/jcs.00331)

2002

• Davis, T. 2002. Comparison of the sexual behaviour gene fruitless between D. melanogaster and two sympatric Hawaiian species, D. heteroneura and D. silvestris. Drosophila Information Service 85, pp. 25-28.

2001

• Edwards, K., Davis, T., Marcey, D., Kurihara, J. and Yamamoto, D. 2001. Comparative analysis of the Band 4.1/ezrin-related protein tyrosine phosphatase Pez from two Drosophila species: implications for structure and function. Gene 275(2), pp. 195-205. (10.1016/S0378-1119(01)00686-2)
• Davis, T. and Ito, H. 2001. Genomic structure of the sexual behaviour gene fruitless. Drosophila Information Service 84, pp. 65-66.

2000

• Gailey, D. A. et al. 2000. Brief report a phylogeny of the Drosophilidae using the sex-behaviour gene fruitless. Hereditas 133(1), pp. 81-83. (10.1111/j.1601-5223.2000.00081.x)
• Davis, T. 2000. On the relationship between the Scaptomyza and the Hawaiian Drosophila [Brief report]. Hereditas 132(3), pp. 257-259. (10.1111/j.1601-5223.2000.00257.x)
• Davis, T., Kurihara, J. and Yamamoto, D. 2000. Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura. Gene 246(1-2), pp. 143-149. (10.1016/S0378-1119(00)00064-0)
• Davis, T., Kurihara, J., Yoshino, E. and Yamamoto, D. 2000. Genomic organisation of the neural sex determination gene fruitless (fuu) in the Hawaiian species Drosophila siluestris and the conservation of the fru BTB protein-protein-binding domain throughout evolution. Hereditas 132(1), pp. 67-78. (10.1111/j.1601-5223.2000.00067.x)

1999

• Ashburner, M. et al. 1999. An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics 153(1), pp. 179-219.

1998

• Helps, N. R., Brewis, N. D., Lineruth, K., Davis, T., Kaiser, K. and Cohen, P. T. 1998. Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos. Journal of Cell Science 111(10), pp. 1331-1340.

1997

• Trikka, D., Davis, T., Lapenta, V., Brahe, C. and Kessling, A. M. 1997. Human COL6A1: Genomic characterization of the globular domains, structural and evolutionary comparison with COL6A2. Mammalian Genome 8(5), pp. 342-345. (10.1007/s003359900436)
• Davis, T., Ashburner, M., Johnson, G., Gubb, D. and Roote, J. 1997. Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Dvosophila melanogaster. Hereditas 126(1), pp. 67-75. (10.1111/j.1601-5223.1997.00067.x)
• Faragher, R. G. A., Hardy, S. P., Davis, T., Dropcova, S. and Allen, M. C. 1997. Cycling Werner's syndrome fibroblasts display calcium-dependent potassium currents. Experimental Cell Research 231(1), pp. 119-122. (10.1006/excr.1996.3437)
• Davis, T. and Shall, S. 1997. Characterisation and expression of a chicken erythroblast mono(ADP-ribosyl)transferase gene [Meeting abstract]. Biochemical Society Transactions 25(1), pp. 80S-80S. (10.1042/bst025080s)
• Davis, T., Sabir, J. S. M., Tavassoli, M. and Shall, S. 1997. Purification, characterisation, and molecular cloning of a chicken erythroblast mono(ADP-ribosyl)transferase. Advances in Experimental Medicine and Biology 419, pp. 145-154. (10.1007/978-1-4419-8632-0_17)

1996

• McNabb, S., Grieg, S. and Davis, T. 1996. The alcohol dehydrogenase gene is nested in the outspread locus of Drosophila melanogaster. Genetics 143(2), pp. 897-911.
• Davis, T. and Ashburner, M. 1996. The chromosomal organisation of the alcohol dehydrogenase region of the genome of Drosophila melanogaster [Communication]. Biochemical Society Transactions 24(1), pp. 109S-109S. (10.1042/bst024109s)

1995

• Davis, T. and Shall, S. 1995. Sequence of a chicken erythroblast mono(ADP-ribosyl)transferase-encoding gene and its upstream region [Brief note]. Gene 164(2), pp. 371-372. (10.1016/0378-1119(95)00504-Y)
• Davis, T. and Shall, S. 1995. Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene [Communication]. Biochemical Society Transactions 23(2), pp. 207S-207S. (10.1042/bst023207s)

1994

• Davis, T. and Lineruth, K. 1994. The characterisation of a P-element insert into the Gsα G protein gene in Drosophila melanogaster [Communication]. Biochemical Society Transactions 22(2), pp. 134S-134S. (10.1042/bst022134s)

1992

• Lineruth, K. and Davis, T. 1992. The isolation and characterization of P-element insertions into G protein genes [Communication]. Biochemical Society Transactions 20(3), pp. 261S-261S. (10.1042/bst020261s)

1990

• Gubb, D., Ashburner, M., Roote, J. and Davis, T. 1990. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Genetics 126(1), pp. 167-176.
• Davis, T., Trenear, J. and Ashburner, M. 1990. The molecular analysis of the el-noc complex of Drosophila melanogaster. Genetics 126(1), pp. 105-119.

1987

• Adams, R. L. P., Davis, T., Rinaldi, A. and Eason, R. 1987. CpG deficiency, dinucleotide distributions and nucleosome positioning. European Journal of Biochemistry 165(1), pp. 107-115. (10.1111/j.1432-1033.1987.tb11200.x)

1986

• Davis, T., Rinaldi, A., Clark, L. and Adams, R. L. P. 1986. Methylation of chromatin in vitro. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 866(4), pp. 233-241. (10.1016/0167-4781(86)90048-5)

1985

• Davis, T., Kirk, D., Rinaldi, A., Burdon, R. H. and Adams, R. L. P. 1985. Delayed methylation and the matrix bound DNA methylase. Biochemical and Biophysical Research Communications 126(2), pp. 678-684. (10.1016/0006-291X(85)90238-4)

1984

• Adams, R. L., Davis, T., Fulton, J., Kirk, D., Qureshi, M. and Burdon, R. H. 1984. Eukaryotic DNA methylase--properties and action on native DNA and chromatin. Current Topics in Microbiology and Immunology 108, pp. 143-156. (10.1007/978-3-642-69370-0_10)