Overview
I am an expert on the nose and upper airways with an interest in human diseases of the upper airways such as common cold and allergy. I established the Common Cold Centre at Cardiff University in 1988 as a clinical trial centre testing new treatments for colds, flu cough etc. The centre closed March 2017 on my retirement from the university. I have been the principal investigator in over 120 clinical trials sponsored by pharmaceutical companies. My special areas of expertise include studies on cough, sore throat, blocked nose, and the mechanisms of the symptoms of cold and flu. I act as a consultant to the pharmaceutical industry and travel widely giving lectures on treatments for colds and flu.
Biography
I attended Leigh Grammar School, Lancashire and then studied for BSc and PhD in Pharmacology at Liverpool University and was later awarded DSc for my research work. I enjoyed many trips to Baghdad and Mosul, Iraq (1985-1990) teaching postgraduate and under graduate clinical physiology at hospitals and universities and was held as a Guest of Saddam in the build up to the First Gulf War in 1990, eventually returning to the UK with Edward Heath and Richard Branson on a special 747 Virgin flight on the 24 October 1990. During my confinement in Baghdad I wrote up some of my lectures given to surgeons in Iraq, which were later published as a text book on Electrolytes, Body Fluids and Acid-Base Balance.
I established the Common Cold Centre at Cardiff University in 1988 with sponsorship from Richardson Vicks Company and Procter and Gamble and the Centre established an international reputation as a centre of excellence for clinical trials on treatments for cough, colds and flu. The Centre closed in March 2017 on my retirement from the university after 44 years service.
I have frequently featured on TV, radio, newspapers and magazines throughout the world discussing all aspects of common cold and flu and am still happy to interact with media on this topic.
Publications
2023
- Eccles, R., Boivin, G., Cowling, B. J., Pavia, A. and Selvarangan, R. 2023. Treatment of COVID-19 symptoms with over the counter (OTC) medicines used for treatment of common cold and flu. Clinical Infection in Practice 19, pp. 100230. (10.1016/j.clinpr.2023.100230)
- Eccles, R. 2023. Common cold. Frontiers in Allergy 4, article number: 1224988. (10.3389/falgy.2023.1224988)
2022
- Jessop, Z. M. et al. 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23(1), article number: 782. (10.1186/s13063-022-06685-z)
- Eccles, R. 2022. Cough and common cold. In: Kenakin, T. ed. Comprehensive Pharmacology., Vol. 4. Elsevier, pp. 745-761., (10.1016/B978-0-12-820472-6.00094-3)
2021
- Eccles, R. 2021. Placebo and side effects confound clinical trials on new antitussives. Lung 199(4), pp. 319-326. (10.1007/s00408-021-00458-2)
- Eccles, R. 2021. Why is temperature sensitivity important for the success of common respiratory viruses?. Reviews in Medical Virology 31(1), pp. 1-8. (10.1002/rmv.2153)
- Eccles, R. 2021. The role of nasal congestion as a defence against respiratory viruses. Clinical Otolaryngology 46(1), pp. 4-8. (10.1111/coa.13658)
2020
- Eccles, R. 2020. What is the role of over 100 excipients in over the counter (OTC) cough medicines?. Lung 198, pp. 727-734. (10.1007/s00408-020-00390-x)
- Eccles, R. 2020. Respiratory mucus and persistence of virus on surfaces. Journal of Hospital Infection 105(2), pp. 350. (10.1016/j.jhin.2020.03.026)
- Eccles, R. 2020. Iota-carrageenan as an antiviral treatment for the common cold. The Open Virology Journal 14(9), pp. 9-15. (10.2174/1874357902014010009)
- Eccles, R. 2020. The powerful placebo effect in cough: Relevance to treatment and clinical trials. Lung 198(1), pp. 13-21. (10.1007/s00408-019-00305-5)
2017
- Eccles, R. and Mallefet, P. 2017. Soothing properties of glycerol in cough syrups for acute cough due to common cold. Pharmacy 5(1), article number: 4. (10.3390/pharmacy5010004)
2016
- Price, A. and Eccles, R. 2016. Nasal airflow and brain activity: is there a link?. The Journal of Laryngology & Otology 130(9), pp. 794-799. (10.1017/S0022215116008537)
- Eccles, R., Dicpinigaitis, P., Turner, R. B., Druce, H. M., Adeleke, M. and Mann, A. L. 2016. Characterization of urge to cough and cough symptoms associated with the common cold: results of a US internet survey. Postgraduate Medicine 128(5), pp. 485-491. (10.1080/00325481.2016.1185376)
- Eccles, R., Turner, R. B. and Dicpinigaitis, P. V. 2016. Treatment of acute cough due to the common cold: multi-component, multi-symptom therapy is preferable to single-component, single-symptom therapy - a pro/con debate. Lung 194(1), pp. 15-20. (10.1007/s00408-015-9808-5)
- Williams, M. and Eccles, R. 2016. A model for the central control of airflow patterns within the human nasal cycle. The Journal of Laryngology & Otology 130(1), pp. 82-88. (10.1017/S0022215115002881)
2015
- Smith, T. et al. 2015. Aspirin in the 21st century - common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK. ecancermedicalscience 9, article number: 581. (10.3332/ecancer.2015.581)
- Eccles, R., Winther, B., Johnston, S. L., Robinson, P., Trampisch, M. and Koelsch, S. 2015. Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial. Respiratory Research 16, article number: 121. (10.1186/s12931-015-0281-8)
- Eccles, R. and Wilkinson, J. E. 2015. Exposure to cold and acute upper respiratory tract infection. Rhinology 53(2), pp. 99-106. (10.4193/Rhin14.239)
- Eccles, R. and Bathala, S. 2015. Assessment of upper airway obstruction by measuring peak oral and nasal inspiratory flow. Journal of Laryngology and Otology 129(5), pp. 473-477. (10.1017/S0022215115000523)
- Williams, M. R. and Eccles, R. 2015. The nasal cycle and age. Acta Oto-laryngologica 135(8), pp. 831-834. (10.3109/00016489.2015.1028592)
- Wong, E. H. C. and Eccles, R. 2015. Comparison of the classic and Broms methods of rhinomanometry using model noses. European Archives of Oto-Rhino-Laryngology 272(1), pp. 105-110. (10.1007/s00405-014-3083-6)
- Dicpinigaitis, P. V., Eccles, R., Blaiss, M. S. and Wingertzahn, M. A. 2015. Impact of cough and common cold on productivity, absenteeism, and daily life in the United States: ACHOO Survey. Current Medical Research and Opinion 31(8), pp. 1519-1525. (10.1185/03007995.2015.1062355)
- Blaiss, M. S., Dicpinigaitis, P. V., Eccles, R. and Wingertzahn, M. A. 2015. Consumer attitudes on cough and cold: US (ACHOO) survey results. Current Medical Research and Opinion 31(8), pp. 1527-1538. (10.1185/03007995.2014.1002558)
2014
- Wong, E. H. and Eccles, R. 2014. Comparison of classic and 4-phase rhinomanometry methods, is there any difference?. Rhinology 52(4), pp. 360-365.
- Eccles, R., Gessner, U. and Volker, M. 2014. Acetylsalicylic acid and pseudoephedrine: effectiveness of the combination in respiratory tract infections [Acetylsalicylsäure und Pseudoephedrin: Wirksamkeit der Kombination bei Infektionen der Atemwege]. Pharmazeutische Zeitung 2014(10), article number: 51169.
- Eccles, R. and Voelker, M. 2014. Analgesic and decongestant efficacy of the combination of aspirin with pseudoephedrine in patients with symptoms of upper respiratory tract infection. Clinical Pharmacology in Drug Development 3(2), pp. 118-125. (10.1002/cpdd.39)
2013
- Eccles, R., Du-Plessis, L., Dommels, Y. and Wilkinson, J. E. 2013. Cold pleasure. Why we like ice drinks, ice-lollies and ice cream. Appetite 71, pp. 357-360. (10.1016/j.appet.2013.09.011)
- Eccles, R. 2013. Is the common cold a clinical entity or a cultural concept?. Rhinology 51(1), pp. 3-8. (10.4193/Rhino12.123)
- Bathala, S. and Eccles, R. 2013. A review on the mechanism of sore throat in tonsillitis. The Journal of Laryngology & Otology 127(3), pp. 227-232. (10.1017/S0022215112003003)
2012
- Moore, M. and Eccles, R. 2012. Normal nasal patency: problems in obtaining standard reference values for the surgeon. Journal of Laryngology and Otology 126(6), pp. 563-569. (10.1017/S002221511200045X)
- Bathala, S. and Eccles, R. 2012. RE: The use of ice lollies for pain relief post-paediatric tonsillectomy [Letter]. Clinical Otolaryngology 37(2), pp. 162-163. (10.1111/j.1749-4486.2012.02453.x)
- Eccles, R. 2012. Misleading article on septoplasty [Letter]. American Journal of Otolaryngology 33(1), pp. 192. (10.1016/j.amjoto.2010.09.016)
- Jawad, M., Schoop, R., Suter, A., Klein, P. and Eccles, R. 2012. Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: a randomized, double-blind, placebo-controlled trial. Evidence Based Complementary and Alternative Medicine, article number: 841315. (10.1155/2012/841315)
2011
- Jones, R., Hilldrup, S., Hope-Gill, B., Eccles, R. and Harrison, N. K. 2011. Mechanical induction of cough in idiopathic pulmonary fibrosis. Cough 7(1), pp. 2-10. (10.1186/1745-9974-7-2)
- Moore, M. and Eccles, R. 2011. Objective evidence for the efficacy of surgical management of the deviated septum as a treatment for chronic nasal obstruction: a systematic review. Clinical Otolaryngology 36(2), pp. 106-113. (10.1111/j.1749-4486.2011.02279.x)
- Eccles, R. 2011. A guide to practical aspects of measurement of human nasal airflow by rhinomanometry. Rhinology 49(1), pp. 2-10.
- Doddi, N. and Eccles, R. 2011. Paradoxical increase in nasal airway resistance following a topical nasal decongestant spray [Letter]. Rhinology 49(1), pp. 127.
- Eccles, R. 2011. Mechanisms of the symptoms of rhinosinusitis. Rhinology 49(2), pp. 131-138.
- Doddi, N. and Eccles, R. 2011. The relationship between nasal index and nasal airway resistance, and response to a topical decongestant. Rhinology 49(5), pp. 583-586.
2010
- Eccles, R., Holbrook, A. and Jawad, M. 2010. A double-blind, randomised, crossover study of two doses of a single-tablet combination of ibuprofen/paracetamol and placebo for primary dysmenorrhoea. Current Medical Research and Opinion 26(11), pp. 2689-2699. (10.1185/03007995.2010.525028)
- Eccles, R., Meier, C., Jawad, M., Weinmüllner, R., Grassauer, A. and Prieschl- Grassauer, E. 2010. Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respiratory Research 11(1), pp. 108-118. (10.1186/1465-9921-11-108)
- Doddi, N. and Eccles, R. 2010. The role of anthropometric measurements in nasal surgery and research: a systematic review. Clinical Otolaryngology 35(4), pp. 277-283. (10.1111/j.1749-4486.2010.02169.x)
- Eccles, R., Doddi, N. and Leong, S. C. 2010. Re: Correlation between subjective and objective evaluation of the nasal airway [Letter]. Clinical Otolaryngology 35(2), pp. 149. (10.1111/j.1749-4486.2010.02101.x)
- Eccles, R., Martensson, K. and Chen, S. 2010. Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold. Current Medical Research and Opinion 26(4), pp. 889-899. (10.1185/03007991003648015)
- Eccles, R. 2010. Importance of placebo effect in cough clinical trials. Lung 188(S1), pp. 53-61. (10.1007/s00408-009-9173-3)
- Leong, S. C. and Eccles, R. 2010. Inferior turbinate surgery and nasal airflow: evidence-based management. Current Opinion in Otolaryngology & Head and Neck Surgery 18(1), pp. 54-59. (10.1097/MOO.0b013e328334db14)
- Leong, S. C. and Eccles, R. 2010. Race and ethnicity in nasal plastic surgery: a need for science. Facial Plastic Surgery 26(2), pp. 63-68. (10.1055/s-0030-1253505)
- Leong, S. C. and Eccles, R. 2010. The use of race as a demographic variable in clinical research. Rhinology 48(1), pp. 3-6.
- Leong, S. C., Farmer, S. and Eccles, R. 2010. Coblation® inferior turbinate reduction: a long-term follow-up with subjective and objective assessment. Rhinology 48(1), pp. 108-112.
2009
- Leong, S. C. and Eccles, R. 2009. A systematic review of the nasal index and the significance of the shape and size of the nose in rhinology. Clinical Otolaryngology 34(3), pp. 191-198. (10.1111/j.1749-4486.2009.01905.x)
- Graf, P., Eccles, R. and Chen, S. 2009. Efficacy and safety of intranasal xylometazoline and ipratropium in patients with common cold. Expert Opinion on Pharmacotherapy 10(5), pp. 889-908. (10.1517/14656560902783051)
- Eccles, R. 2009. Central mechanisms IV: conscious control of cough and the placebo effect. In: Chung, K. F. and Widdicombe, J. eds. Pharmacology and Therapeutics of Cough. Handbook of experimental pharmacology Vol. 187. Berlin: Springer-Verlag, pp. 241-262.
- Leong, S. C. and Eccles, R. 2009. What defines a Thai, Caucasian, or Asian? [Letter]. American Journal of Rhinology & Allergy 23(2), pp. 238. (10.2500/ajra.2009.23.3302)
- Leong, S. C. and Eccles, R. 2009. Letter to the editor. American Journal of Rhinology and Allergy 23(2), pp. 238-238.
2008
- Farmer, S., Quine, S. and Eccles, R. 2008. Efficacy of inferior turbinate coblation for treatment of nasal obstruction. The Journal of Laryngology & Otology 123(3), pp. 309-314. (10.1017/S0022215108002818)
- Eccles, R., Eriksson, M., Garreffa, S. and Chen, S. 2008. The nasal decongestant effect of xylometazoline in the common cold. American Journal of Rhinology 22(5), pp. 491-496. (10.2500/ajr.2008.22.3202)
- Sanu, A. and Eccles, R. 2008. Postnasal drip syndrome. Two hundred years of controversy between UK and USA. Rhinology 43, pp. 86-91.
- Sanu, A. and Eccles, R. 2008. The effects of a hot drink on nasal airflow and symptoms of common cold and flu. Rhinology 46(4), pp. 271-275.
- Eccles, R. and Sanu, A. 2008. Reply from authors. Rhinology 46(4), pp. 348.
2007
- Eccles, R. 2007. Efficacy of phenylephrine. British Journal of Clinical Pharmacology 64(4), pp. 557. (10.1111/j.1365-2125.2007.02936.x)
- Farmer, S. E. J. and Eccles, R. 2007. Understanding submucosal electrosurgery for the treatment of nasal turbinate enlargement. The Journal of Laryngology & Otology 121(7), pp. 615-622. (10.1017/S0022215106004038)
- Boyce, J. and Eccles, R. 2007. Response to Sharma et al.. Clinical Otolaryngology 32(1), pp. 72. (10.1111/j.1365-2273.2007.01366.x)
- Eccles, R. 2007. Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse. British Journal of Clinical Pharmacology 63(1), pp. 10-14. (10.1111/j.1365-2125.2006.02833.x)
- Eccles, R., Pedersen, A., Regberg, D., Tulento, H., Borum, P. and Stjärne, P. 2007. Efficacy and safety of topical combinations of ipratropium and xylometazoline for the treatment of symptoms of runny nose and nasal congestion associated with acute upper respiratory tract infection. American Journal of Rhinology & Allergy 21(1), pp. 40-45. (10.2500/ajr.2007.21.2902)
- Eccles, R. 2007. The power of the placebo. Current Allergy and Asthma Reports 7(2), pp. 100-104. (10.1007/s11882-007-0006-2)
- Ali, Z. et al. 2007. Efficacy of a paracetamol and caffeine combination in the treatment of the key symptoms of primary dysmenorrhoea. Current Medical Research and Opinion 23(4), pp. 841-851. (10.1185/030079907X182239)
- Eccles, R. 2007. Query, concerning mechanism of inferior turbinate enlargement. JAMA Otolaryngology - Head and Neck Surgery 133(6), pp. 624-624. (10.1001/archotol.133.6.624-a.)
- Eccles, R. 2007. Mechanisms of symptoms of the common cold and influenza. British Journal of Hospital Medicine 68(2), pp. 71-75. (10.12968/hmed.2007.68.2.22824)
2006
- Eccles, R. 2006. Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. Journal of Clinical Pharmacy and Therapeutics 31(4), pp. 309-319. (10.1111/j.1365-2710.2006.00754.x)
- Boyce, J. M. and Eccles, R. 2006. Assessment of subjective scales for selection of patients for nasal septal surgery. Clinical Otolaryngology 31(4), pp. 297-302. (10.1111/j.1749-4486.2006.01243.x)
- Eccles, R. 2006. Mechanisms of the placebo effect of sweet cough syrups. Respiratory Physiology & Neurobiology 152(3), pp. 340-348. (10.1016/j.resp.2005.10.004)
- Eccles, R. 2006. Re: Effects of unilateral naris closure on the nasal and maxillary sinus mucosa in rabbit by Seung-Heon Shin and Won-Wook Heo, Auris Nasus Larynx 32 (2005) 139-143.[Letter]. Auris Nasus Larynx 33(1), pp. 117. (10.1016/j.anl.2005.11.001)
- Boyce, J. and Eccles, R. 2006. Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review. Clinical Otolaryngology 31(1), pp. 15-19. (10.1111/j.1749-4486.2006.01125.x)
- Clare, J. D., Hopkins, M. L. and Eccles, R. 2006. How good are patients at determining which side of the nose is more obstructed? A study on the limits of discrimination of the subjective assessment of unilateral nasal obstruction. American Journal of Rhinology 20(1), pp. 20-24.
- Eccles, R., Jawad, M., Jawad, S., Ridge, D., North, M., Jones, E. and Burnett, I. 2006. Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. Current Medical Research and Opinion 22(12), pp. 2411-2418. (10.1185/030079906X154105)
- Widdicombe, J., Eccles, R. and Fontana, G. 2006. Supramedullary influences on cough. Respiratory Physiology & Neurobiology 152(3), pp. 320-328. (10.1016/j.resp.2006.02.018)
- Irwin, R. S. and Eccles, R. 2006. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest 129(1_supp), pp. 1S. (10.1378/chest.129.1_suppl.1S)
- Farmer, S. E. J. and Eccles, R. 2006. Chronic inferior turbinate enlargement and the implications for surgical intervention. Rhinology 44, pp. 234-238.
- Eccles, R. 2006. Is a normal range of nasal function beyond the reach of rhinologists?. American Journal of Rhinology 20(2), pp. 205-205.
2005
- Johnson, C. and Eccles, R. 2005. Acute cooling of the feet and the onset of common cold symptoms. Family Practice 22(6), pp. 608-613. (10.1093/fampra/cmi072)
- Lee, P. C. L., Jawad, M. S. M., Hull, J. D., West, W. H. L., Shaw, K. and Eccles, R. 2005. The antitussive effect of placebo treatment on cough associated with acute upper respiratory infection. Psychosomatic Medicine 67(2), pp. 314-317. (10.1097/01.psy.0000155667.59662.92)
- Nathan, R., Eccles, R., Howarth, P., Steinsvag, S. and Togias, A. 2005. Objective monitoring of nasal patency and nasal physiology in rhinitis. Journal of Allergy and Clinical Immunology 115(3), pp. S442. (10.1016/j.jaci.2004.12.015)
- Clarke, J. D., Hopkins, M. L. and Eccles, R. 2005. Evidence for correlation of objective and subjective measures of nasal airflow in patients with common cold. Clinical Otolaryngology 30(1), pp. 35-38. (10.1111/j.1365-2273.2004.00915.x)
- Clarke, J. D. and Eccles, R. 2005. Paradoxical sensation of nasal airflow in patients with common cold. Are we measuring the correct modality?. Acta Oto-laryngologica 125(12), pp. 1307-1311. (10.1080/00016480510043404)
- Eccles, R. 2005. Understanding the symptoms of the common cold and influenza. The Lancet Infectious Diseases 5(11), pp. 718-725. (10.1016/S1473-3099(05)70270-X)
- Eccles, R. 2005. Placebo research and the spirit of informed consent: response. Psychosomatic Medicine 67(4), pp. 678. (10.1097/01.psy.0000172146.62930.e2)
- Eccles, R. 2005. Asymptomatic spread of flu is not proved. British Medical Journal 331, pp. 1145-1145. (/10.1136/bmj.331.7525.1145)
- Eccles, R., Jawad, M., Jawad, S. S. M., Angello, J. T. and Druce, H. M. 2005. Efficacy and safety of single and multiple doses of pseudoephedrine in the treatment of nasal congestion associated with common cold. American Journal of Rhinology 19(1), pp. 25-31.
2004
- Eccles, R. and Bolser, D. C. 2004. Discussion on poster presentations. Pulmonary Pharmacology and Therapeutics 17(6), pp. 469-470. (10.1016/j.pupt.2004.09.003)
- Davis, S. S. and Eccles, R. 2004. Nasal congestion: mechanisms, measurement and medications. Core information for the clinician. Clinical Otolaryngology 29(6), pp. 659-666. (10.1111/j.1365-2273.2004.00885.x)
- Eccles, R. and Lee, P. C. L. 2004. Cough induced by airway vibration as a model of airway hyperreactivity in patients with acute upper respiratory tract infection. Pulmonary Pharmacology and Therapeutics 17(6), pp. 337-342. (10.1016/j.pupt.2004.09.011)
- Lee, P. C. L. and Eccles, R. 2004. Cough induction by high-frequency chest percussion in healthy volunteers and patients with common cold. Respiratory Medicine 98(8), pp. 771-776. (10.1016/j.rmed.2004.01.006)
- Eccles, R. and Jawad, M. 2004. Drink plenty of fluids [Letter]. British Medical Journal 328(7445), pp. 957.
- Lee, P. and Eccles, R. 2004. Cough induced by mechanical stimulation of the upper airway in humans. Acta Oto-laryngologica 124(6), pp. 720-725. (10.1080/00016480410017251)
- Lund, V. J., Grouin, J. M., Eccles, R., Bouter, C. and Chaboile, F. 2004. Efficacy of fusafungine in acute rhinopharyngitis: A poole analysis. Rhinology 42(4), pp. 207-212.
2003
- Cuddihy, P. J. and Eccles, R. 2003. The use of nasal spirometry as an objective measure of nasal septal deviation and the effectiveness of septal surgery. Clinical Otolaryngology 28(4), pp. 325-330. (10.1046/j.1365-2273.2003.00714.x)
- Eccles, R., Loose, I., Jawad, M. and Nyman, L. 2003. Effects of acetylsalicylic acid on sore throat pain and other pain symptoms associated with acute upper respiratory tract infection. Pain Medicine 4(2), pp. 118-124. (10.1046/j.1526-4637.2003.03019.x)
- Cuddihy, P. J. and Eccles, R. 2003. The use of nasal spirometry for the assessment of unilateral nasal obstruction associated with changes in posture in healthy subjects and subjects with upper respiratory tract infection. Clinical Otolaryngology 28(2), pp. 108-111. (10.1046/j.1365-2273.2003.00674.x)
- Eccles, R. 2003. Menthol: effects on nasal sensation of airflow and the drive to breathe. Current Allergy and Asthma Reports 3(3), pp. 210-214.
- Hanif, J., Jawad, S. S. M. and Eccles, R. 2003. A study to assess the usefulness of a portable spirometer to quantify the severity of nasal septal deviation. Rhinology 14(1), pp. 11-15.
- Roblin, D. G. and Eccles, R. 2003. Normal range for nasal partitioning of airflow determined by nasal spirometry in 100 healthy subjects. American Journal of Rhinology 17(4), pp. 179-183.
2002
- Lee, P. C. L., Cotterill-Jones, C. and Eccles, R. 2002. Voluntary control of cough. Pulmonary Pharmacology and Therapeutics 15(3), pp. 317-320. (10.1006/pupt.2002.0365)
- Eccles, R. 2002. The powerful placebo in cough studies?. Pulmonary Pharmacology and Therapeutics 15(3), pp. 303-308. (10.1006/pupt.2002.0364)
- Roblin, D. and Eccles, R. 2002. What, if any, is the value of septal surgery?. Clinical Otolaryngology 27(2), pp. 77-80. (10.1046/j.1365-2273.2002.00531.x)
- Eccles, R. 2002. An explanation for the seasonality of acute upper respiratory tract viral infections. Acta Oto-laryngologica 122(2), pp. 183-191. (10.1080/00016480252814207)
- Eccles, R. 2002. Acute cooling of the body surface and the common cold. Rhinology 40(3), pp. 109-114.
2001
- Hanif, J., Jawad, S. S. M. and Eccles, R. 2001. Use of a portable spirometer for studies on the nasal cycle. American Journal of Rhinology 15(5), pp. 303-306.
2000
- Hanif, J., Jawad, S. S. M. and Eccles, R. 2000. The nasal cycle in health and disease. Clinical Otolaryngology 25(6), pp. 461-467. (10.1046/j.1365-2273.2000.00432.x)
- Eccles, R. 2000. Nasal airflow in health and disease. Acta Oto-laryngologica 120(5), pp. 580-595. (10.1080/000164800750000388)
- Hadjikoutis, S., Eccles, R. and Wiles, C. M. 2000. Coughing and choking in motor neuron disease. Journal of Neurology, Neurosurgery & Psychiatry 68(5), pp. 601-604. (10.1136/jnnp.68.5.601)
- Takeuchi, H., Jawad, M. and Eccles, R. 2000. Changes in unilateral nasal airflow in patients with seasonal allergic rhinitis measured in and out of season. Auris Nasus Larynx 27(2), pp. 141-145. (10.1016/S0385-8146(99)00058-9)
- Eccles, R. 2000. Role of cold receptors and menthol in thirst, the drive to breathe and arousal. Appetite 34(1), pp. 29-35. (10.1006/appe.1999.0291)
- Lee, P. C. L., Jawad, M. S. M. and Eccles, R. 2000. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. African Journal of Pharmacy and Pharmacology 52(9), pp. 1137-1142.
- Eccles, R. 2000. Pathophysiology of nasal symptoms. American Journal of Rhinology 14(5), pp. 335-338. (10.2500/105065800781329528)
- Eccles, R. 2000. The nasal cycle in respiratory defence. Acta Oto-Rhino-Laryngologica Belgica 54(5), pp. 281-286.
1996
- Freestone, C., Eccles, R., Morris, S. and Jawad, M. S. M. 1996. Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. Pulmonary Pharmacology 9(5-6), pp. 365. (10.1006/pulp.1996.0048)
My research has involved understanding how the symptoms of cough, cold and flu are generated and developing methods of assessing the symptoms in clinical trials on new treatments for cough, colds and flu. My areas of expertise include assessment of the efficacy of; nasal decongestants, using both objective methods such as rhinomanometry and acoustic rhinometry and subjective scores; analgesics, using the sore throat as a model; herbal medicines using general symptom scores; antitussives, using various methods of cough counting and subjective scores.
