Overview
If you are a patient, thank you for reaching out to me after seeing the article about our research. It is at an early stage and although we are hopeful that these new cells will be therapeutically valuable, they have yet to be tested and approved for clinical trials. For more support please contact a cancer support group in your local area.
Research
Thesis
Hitting a moving target: The role of peptide-HLA flexibility during autoimmunity, transplant rejection, cancer and pathogen detection.
Publications
2024
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- Ferrari, M. et al. 2024. Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. Nature Communications 15(1), article number: 1583. (10.1038/s41467-024-45854-3)
2021
- Hopkins, J. 2021. Plasticity at the T cell receptor-peptide-major
histocompatibility complex class I interface. PhD Thesis, Cardiff University.
2020
- Hopkins, J. R. et al. 2020. Peptide cargo tunes a network of correlated motions in human leukocyte antigens. FEBS Journal 287(17), pp. 3777-3793. (10.1111/febs.15278)
- Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11, article number: 296. (10.3389/fimmu.2020.00296)
2019
- Madura, F. et al. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49(7), pp. 1052-1066. (10.1002/eji.201948085)