Research
Thesis
Chemical Genetic Inhibition of E2 ubiquitin-conjugating enzyme
Supervisors
Dr Louis Luk
Senior Lecturer in Biological Chemistry
Publications
2023
- Spear, L. 2023. Chemical genetic inhibition of E2 ubiquitin-conjugating enzymes. PhD Thesis, Cardiff University.
2022
- Spear, L. A., Huang, Y., Chen, J., Nödling, A. R., Virdee, S. and Tsai, Y. 2022. Selective inhibition of cysteine-dependent enzymes by bioorthogonal tethering. Journal of Molecular Biology 434, article number: 167524. (10.1016/j.jmb.2022.167524)
2019
- Nodling, A. R., Spear, L. A., Williams, T. L., Luk, L. Y. and Tsai, Y. 2019. Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells. Essays in Biochemistry 63(2), pp. 237-266. (10.1042/EBC20180042)