Dr Ilaria Morella

2023

• Morella, I., Negro, M., Dossena, M., Brambilla, R. and D'Antona, G. 2023. Gut-muscle-brain axis: Molecular mechanisms in neurodegenerative disorders and potential therapeutic efficacy of probiotic supplementation coupled with exercise. Neuropharmacology 240, article number: 109718. (10.1016/j.neuropharm.2023.109718)
• Kretz, P. F. et al. 2023. Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein. Genome Biology 24, article number: 261. (10.1186/s13059-023-03092-8)
• Indrigo, M. et al. 2023. Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2. EMBO Molecular Medicine 15(11), article number: e15984. (10.15252/emmm.202215984)
• Pisanò, C. A. et al. 2023. Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia. British Journal of Pharmacology 180(7), pp. 927-942. (10.1111/bph.15730)

2022

• Morella, I. M., Brambilla, R. and Morè, L. 2022. Emerging roles of brain metabolism in cognitive impairment and neuropsychiatric disorders. Neuroscience & Biobehavioral Reviews 142, article number: 104892. (10.1016/j.neubiorev.2022.104892)
• Morella, I., Pohořalá, V., Calpe-López, C., Brambilla, R., Spanagel, R. and Bernardi, R. E. 2022. Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice. Frontiers in Pharmacology 13, article number: 986566. (10.3389/fphar.2022.986566)

2020

• Morella, I., Hallum, H. and Brambilla, R. 2020. Dopamine D1 and glutamate receptors co-operate with brain-derived neurotrophic factor (BDNF) and TrkB to modulate ERK signaling in adult striatal slices. Frontiers in Cellular Neuroscience 14, article number: 564106. (10.3389/fncel.2020.564106)

2019

• Bernardi, R. E., Olevska, A., Morella, I., Fasano, S., Santos, E., Brambilla, R. and Spanagel, R. 2019. The inhibition of RasGRF2, but not RasGRF1, alters cocaine reward in mice. Journal of Neuroscience 39(32), pp. 6325-6338. (10.1523/JNEUROSCI.1120-18.2019)

2018

• Pucilowska, J. et al. 2018. Pharmacological inhibition of ERK signaling rescues pathophysiology and behavioral phenotype associated with 16p11.2 chromosomal deletion in mice. Journal of Neuroscience 38(30), pp. 6640-6652. (10.1523/JNEUROSCI.0515-17.2018)
• Arcuri, L. et al. 2018. Anti-parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists. British Journal of Pharmacology 175(5), pp. 782-796. (10.1111/bph.14123)

2016

• Papale, A. et al. 2016. Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors. eLife 5, article number: e17111. (10.7554/eLife.17111)

2015

• Trusel, M. et al. 2015. Coordinated regulation of synaptic plasticity at striatopallidal and sriatonigral neurons orchestrates motor control. Cell Reports 13(7), pp. 1353-1365. (10.1016/j.celrep.2015.10.009)
• Moncini, S., Bonati, M. T., Morella, I., Ferrari, L., Brambilla, R. and Riva, P. 2015. Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family. European Journal of Human Genetics 23(11), pp. 1531-1537. (10.1038/ejhg.2015.20)
• Cerovic, M. et al. 2015. Derangement of Ras-guanine nucleotide-releasing Factor 1 (Ras-GRF1) and extracellular signal-regulated kinase (ERK) dependent striatal plasticity in L-DOPA-induced dyskinesia. Biological Psychiatry 77(2), pp. 106-115. (10.1016/j.biopsych.2014.04.002)

2012

• Orellana, D., Morella, I., Indrigo, M., Papale, A. and Brambilla, R. 2012. The extracellular signal-regulated kinase (ERK) cascade in neuronal cell signaling. In: Protein Kinase Technologies., Vol. 68. Neuromethods Totowa, NJ: Humana Press, pp. 133--152., (10.1007/978-1-61779-824-5_8)

2010

• Longoni, M. et al. 2010. Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations. American Journal of Medical Genetics Part A 152A(9), pp. 2176-2184. (10.1002/ajmg.a.33564)