Ewch i’r prif gynnwys
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd

Asesiad aml-raddol ac amlfodd o ymglymiad yn yr ymennydd iach ac afiach

a colourful mri brain scan showing the connections inside the human brain
A brain scan acquired by the Siemens 3 Tesla Connectom MRI scanner.

Ein nod yw dyfnhau’n sylweddol ein dealltwriaeth o sut mae systemau gwahanol yr ymennydd (trydanol, cemegol, strwythurol, metabolig) yn rhyngweithio a’i gilydd a sut mae gwahaniaethau yn y rhyngweithio hyn yn effeithio ar swyddogaeth ac ymddygiad yr ymennydd.

Datblygwyd amrywiaeth o dechnegau niwroddelweddu i brocio systemau gwahanol. Rydym yn gwneud y rhain fel mater o drefn, ond nid ydyn yn deall beth y maent yn mesur, ac os ydynt yn dweud y stori lawn wrthynt am iechyd a/neu glefyd.

Hefyd, ni wyddom sut mae signalau o dechnegau gwahanol yn cysylltu â'i gilydd. Yn y rhaglen hon, rydym yn astudio pobl iach a phobl lle rydym eisoes yn gwybod bod gwahaniaethau mewn cyplu gan gynnwys pobl ag epilepsi a seicosis. Yr ydym hefyd yn astudio cyplu cyn ac ar ôl tarfu ar yr ymennydd, drwy hyfforddiant yr ymennydd, symbyliad magnetig neu drin ffaramacolegol.

Ein gweledigaeth yw cyflwyno newid sylweddol o ran deall yr ymennydd dynol, trwy greu rhaglen ddelweddu sy'n cyfuno’r arbenigedd, offer a thechnegau niwroddelweddu gorau.

Rydym eisiau ateb y cwestiwn sylfaenol o sut mae rhyngweithio parhaus prosesau trydanol, cemegol, fasgwlaidd a metabolig yn arwain at y gweithgaredd rhwydwaith ar raddfa sy’n tanategu gwahaniaethau rhyng-unigol mewn gwybyddiaeth, a newidiadau allweddol ymddygiadol/swyddogaethol ymennydd mewn clefyd.

Bydd y nodweddiad integredig hwn o ymgysylltu ymennydd dros feysydd lluosog yn trawsnewid ein dealltwriaeth o’r ymennydd gweithredol ac yn arwain at anelu at gamau adfer pan fydd ymgysylltu arferol yn cael ei amharu.

Nodau allweddol

Tîm o 11 cymrodyr methodolegol a 2 clinigol, pob un yn canolbwyntio ar agwedd benodol o gyplu, ond wedi ei gymhwyso o fewn fframwaith systematig o integreiddio, bydd yn caniatáu inni gyflawni ein nodau allweddol, a hynny fydd:

  • optimeiddio cipio signalau gan ddefnyddio’r technolegau delweddu mwyaf datblygedig i gynhyrchu
    marcwyr o strwythur/swyddogaeth sensitif, gadarn a amlroddadwy
  • yn deall yr arwyddion hyn ac felly yn sicrhau eu dehongli biolegol a'u gwerth i fodelau niwrogwybyddol o ymddygiad dynol
  • datblygu fframwaith modelu integreiddiol am gyfuno data o'r dulliau delweddu lluosog
  • nodweddu newidiadau mewn ymglymiad aml-maint yn dilyn aflonyddiad, gan gynnwys
    ymyriadau ymddygiadol, electromagnetig a ffarmacolegol.

Cyllid

Gwnaed y prosiect hwn yn bosibl gan Wobr Strategol Ymddiriedolaeth Wellcome. Dysgwch fwy am ein arianwyr.

Tîm ymchwil

Cyd-ymgeiswyr ar y Dyfarniad

A volunteer is prepared for the MRI scanner
A volunteer is prepared for the MRI scanner

Cyhoeddiadau yn cydnabod y Wobr

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  • Petrican R, Graham KS, Lawrence AD. Brain-environment alignment during movie watching predicts fluid intelligence and affective function in adulthood. Neuroimage. 202Sep;23118177. doi: 10.1016/j.neuroimage.2021.118177. Epub 202May 18. PMID: 34020016; PMCID: PMC8350144.
  • Postans M, Parker GD, Lundell H, Ptito M, Hamandi K, Gray WP, Aggleton JP, Dyrby TB, Jones DK, Winter M. Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory. Cereb Cortex. 2020 Mar 14;30(3):1001-1015. doi: 10.1093/cercor/bhz143. PMID: 31364703; PMCID: PMC7132945.
  • Powell G, Derry-Sumner H, Rajenderkumar D, Rushton SK, Sumner P. Persistent postural perceptual dizziness is on a spectrum in the general population. Neurology. 2020 May 5;94(18):e1929-e1938. doi: 10.1212/WNL.0000000000009373. Epub 2020 Apr 16. PMID: 32300064; PMCID: PMC7274923.
  • Powell G, Derry-Sumner H, Shelton K, Rushton S, Hedge C, Rajenderkumar D, Sumner P. Visually-induced dizziness is associated with sensitivity and avoidance across all senses. J Neurol. 2020 Aug;267(8):2260-2271. doi: 10.1007/s00415-020-09817-0. Epub 2020 Apr 18. PMID: 32306170; PMCID: PMC7359147.
  • Routley B, Shaw A, Muthukumaraswamy SD, Singh KD, Hamandi K. Juvenile myoclonic epilepsy shows increased posterior theta, and reduced sensorimotor beta resting connectivity. Epilepsy Res. 2020 Jul;16106324. doi: 10.1016/j.eplepsyres.2020.106324. Epub 2020 Apr 2. PMID: 32335503; PMCID: PMC7684644.
  • Rudrapatna U, Parker GD, Roberts J, Jones DK. A comparative study of gradient nonlinearity correction strategies for processing diffusion data obtained with ultra-strong gradient MRI scanners. Magn Reson Med. 202Feb;85(2):1104-1113. doi: 10.1002/mrm.28464. Epub 2020 Oct 3. PMID: 33009875; PMCID: PMC8103165.
  • Shaw AD, Muthukumaraswamy SD, Saxena N, Sumner RL, Adams NE, Moran RJ, Singh KD. Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine. Neuroimage. 2020 Nov 1;22117189. doi: 10.1016/j.neuroimage.2020.117189. Epub 2020 Jul 23. PMID: 32711064; PMCID: PMC7762824.
  • St-Jean S, Viergever MA, Leemans A. Harmonization of diffusion MRI data sets with adaptive dictionary learning. Hum Brain Mapp. 2020 Nov;41(16):4478-4499. doi: 10.1002/hbm.25117. Epub 2020 Aug 26. PMID: 32851729; PMCID: PMC7555079.
  • Sumner P, Schwartz L, Woloshin S, Bratton L, Chambers C. Disclosure of study funding and author conflicts of interest in press releases and the news: a retrospective content analysis with two cohorts. BMJ Open. 202Jan 8;11(1):e041385. doi: 10.1136/bmjopen-2020-041385. PMID: 33419908; PMCID: PMC7798706.
  • Tax CMW, Kleban E, Chamberland M, Baraković M, Rudrapatna U, Jones DK. Measuring compartmental T2-orientational dependence in human brain white matter using a tiltable RF coil and diffusion-Tcorrelation MRI. Neuroimage. 202Aug 1;23117967. doi: 10.1016/j.neuroimage.2021.117967. Epub 202Apr 29. PMID: 33845062; PMCID: PMC8270891.
  • Tax CMW, Szczepankiewicz F, Nilsson M, Jones DK. The dot-compartment revealed? Diffusion MRI with ultra-strong gradients and spherical tensor encoding in the living human brain. Neuroimage. 2020 Apr 15;21116534. doi: 10.1016/j.neuroimage.2020.116534. Epub 2020 Jan 11. PMID: 31931157; PMCID: PMC7429990.
  • Tong Q, Gong T, He H, Wang Z, Yu W, Zhang J, Zhai L, Cui H, Meng X, Tax CWM, Zhong J. A deep learning-based method for improving reliability of multicenter diffusion kurtosis imaging with varied acquisition protocols. Magn Reson Imaging. 2020 Nov;731-44. doi: 10.1016/j.mri.2020.08.001. Epub 2020 Aug 18. PMID: 32822818.
  • Veraart J, Nunes D, Rudrapatna U, Fieremans E, Jones DK, Novikov DS, Shemesh N. Nonivasive quantification of axon radii using diffusion MRI. Elife. 2020 Feb 12;e49855. doi: 10.7554/eLife.49855. PMID: 32048987; PMCID: PMC7015669.
  • Williams AN, Ridgeway S, Postans M, Graham KS, Lawrence AD, Hodgetts CJ. The role of the pre-commissural fornix in episodic autobiographical memory and simulation. Neuropsychologia. 2020 May;14107457. doi: 10.1016/j.neuropsychologia.2020.107457. Epub 2020 Apr 4. PMID: 32259556; PMCID: PMC7322517.
  • Yeh CH, Jones DK, Liang X, Descoteaux M, Connelly A. Mapping Structural Connectivity Using Diffusion MRI: Challenges and Opportunities. J Magn Reson Imaging. 202Jun;53(6):1666-1682. doi: 10.1002/jmri.27188. Epub 2020 Jun 17. PMID: 32557893.
A participant lies in an MRI scanner while a male and female researcher operate the scanner
Mae ymchwilwyr yn perfformio sgan MRI ar wirfoddolwr.

Rhagargraffiadau yn cydnabod y Wobr

A male participant prepares to slide a female participant into the bore of a white mri scanner
Our Siemens 3 Tesla Connectom scanner allows researchers to probe tissue microstructure in much finer detail than conventional MR systems.

Crynodebau a dderbyniwyd

  • A. N. Williams, S. Ridgeway, M. Postans, K. S. Graham, A. D. Lawrence, C. J. Hodgetts;
    Cardiff Univ. Brain Res. Imaging Ctr., Cardiff Univ., Cardiff, United Kingdom. Connecting the past and the future: The role of the pre-commissural fornix in episodic autobiographical memory and simulation. Program No. 170.04. 2019 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2019. Online
  • A. N. Williams, M. Postans, C. J. Hodgetts, S. Kusmia, R. Lissaman, D. Hucker, J. Allen, A. D. Lawrence, K. S. Graham;
    Cardiff Univ. Brain Res. Imaging Ctr. (CUBRIC), Sch. of Psychology, Cardiff Univ., Cardiff, United Kingdom; Avon Longitudinal Study of Parents and Children (ALSPAC), Univ. of Bristol, Bristol, United Kingdom. Thinking outside the box: A new role for hippocampal subfields in boundary extension. Program No. 456.01. 2019 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2019. Online
  • M. Postans, A. N. Williams, M. Stefani, R. Lissaman, B. S. Kolarik, A. P. Yonelinas, A. D. Ekstrom, A. D. Lawrence, J. Zhang, K. S. Graham, C. J. Hodgetts;
    Sch. of Psychology, Cardiff Univ., Cardiff, United Kingdom; Ctr. for the Neurobio. of Learning & Memory, Univ. of California, Irvine, CA; Dept. of Psychology, Univ. of California, Davis, Davis, CA; Psychology, Univ. of Arizona, Tucson, AZ. The role of the pre-commissural fornix in an extended neuroanatomical network for goal-directed navigation . Program No. 272.11. 2019 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2019. Online
  • A. Valji, A. Costigan, C. J. Hodgetts, M.-L. Read, K. S. Graham, A. Lawrence, M. Gruber;
    Cardiff Univ. Brain Res. Imaging Ctr., Cardiff Univ., Cardiff, United Kingdom. Curious connections: White matter microstructure correlates of types of curiosity. Program No. 335.21. 2018 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2018. Online
  • Hett K, Patitucci E, Chandler H, Germuska M, Hope-Gill B, Wise R. Locally reduced cerebral blood flow in patients with Idiopathic Pulmonary Fibrosis. International Society for Magnetic Resonance in Medicine, Australia, 2020
  • Jenkins C , Kleban E , Mueller L , Evans CJ , Rudrapatna U , Jones DK, Branzoli F, Ronen I, and CMW Tax. Practical considerations of dMRS with ultra-strong gradients. International Society for Magnetic Resonance in Medicine, Australia, 2020
  • Chandler H L et al.
    Quantification of cerebral grey matter vascular and metabolic function in multiple sclerosis using dual-calibrated fMRI. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Chandler H L et al.
    Mapping brain oxygen metabolism with dual calibrated fMRI in pre-surgical evaluation of epilepsy: a case report comparison with FDG-PET. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Drakesmith M, Rudrapatna SU, Jones DK.
    Mapping axonal conduction velocities from in vivo MRI data. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Power Pitch)
  • Drakesmith M, Kleban E, Fasano F, Rudrapatna SU, Jones DK.
    Improved estimates of the g-ratio by modelling its contribution to complex signal evolution in GRE data. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Germuska M, Chandler HL, Stickland RC, Foster C, Steventon J, Tomassini V, Murphy K, Wise RG.
    A frequency-domain machine learning (FML) method for dual-calibrated estimation of oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen metabolism (CMRO2). International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Jenkins C, Chandler M, Langbein F, Shermer S.
    Quantification of edited magnetic resonance spectroscopy: a comparative phantom based study of analysis methods. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Koller K, Rudrapatna SU, Chamberland M, Raven EP, Parker GD, Tax CMW, Drakesmith M, Evans CJ, Wood TC, Jones DK.
    Powering Up Microstructural Imaging: assessing cross-metric and cross-tract statistical power on an ultra-strong gradient MRI system. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Kopanoglu E, Tachrount M, Meliado EF, Klomp D, Evans J, Wise RG.
    Random RF Shimming may conceal possible local SAR hotspots for asymmetric parallel transmit coils. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Mueller L, Rudrapatna SU, Tax CMW, Wise RG, Jones DK.
    Diffusion MRI with b=1000 s/mm2 at TE < 22 ms using single-shot spiral readout and ultra-strong gradients: Implications for microstructure imaging. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Oral)
  • Rudrapatna SU, Mueller L, Venzi M, Wise RG, Jones DK.
    Can unprecedented echo times in human diffusion weighted fMRI help reveal its biological underpinnings? International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Rudrapatna SU, Mueller L, Wright ME, Jones DK, Wise RG.
    A GRANDIOSE sequence to time-lock BOLD and diffusion-weighted fMRI contrasts in humans using ultra-strong gradients and spirals. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Power Pitch)
  • Tachrount M, Woorward B, Kopanoglu E, Italiaander M, Klomp D, Driver I, Wise R.
    Improving RF efficiency in the brain and the neck at 7T using a novel pTx coil. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Tax CMW, Rudrapatna SU, Mueller L, Jones DK.
    Characterizing diffusion of myelin water in the living human brain using ultra-strong gradients and spiral readout. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Oral)
  • Champagne A, Germuska M, Coverdale NS, Cook DJ.
    Multi-parametric analysis reveals metabolic and vascular effects driving differences in BOLD cerebrovascular reactivity associated with a history of sport concussion. International Society for Magnetic Resonance in Medicine, Montreal, 2019 (Digital Poster)
  • Rossiter HE. Oscillatory dynamics during ischemic pain. MEG UK, Cardiff, 2019. (Poster presentation)
  • Rossiter HE. Exploring cortical correlates of hand kinematics using an RSA based approach with fMRI and MEG data. MEG UK, Cardiff, 2019. (Session presentation)
  • Rossiter HE. Exploring cortical correlates of hand kinematics with fMRI and MEG. UK Sensorimotor Conference, London, 2019. (Talks session presentation)
  • Hedge, C., Powell, G., Bompas, A., & Sumner, P. If common mechanisms of inhibition existed, would we be able to detect them? Twenty-first meeting of the European Society for Cognitive Psychology (ESCOP), Potsdam, Germany, 2019. (Poster presentation)
  • Hedge, C., Powell, G., & Sumner, P. The reliability paradox: Why robust cognitive tasks do not produce reliable individual differences. The 1st Mathematical Cognition and Learning Society Conference, Oxford, UK, 2018. (Talk presentation)
  • Hedge, C., Powell, G., & Sumner, P. The costs of caution: How strategic changes influence the correlations between RT costs and error costs in choice RT tasks. The Twentieth meeting of the European Society for Cognitive Psychology (ESCOP), Potsdam, Germany, 2017. (Poster presentation)
  • Hedge, C. Crossing the desert: Understanding individual differences in cognitive control. University of Ghent, Belgium, December 2019
  • Hedge, C. Translating experimental tasks to the study of individual differences. University of Sheffield, UK, December 2018