Academic publications

2024

• Badder, L. et al. 2024. The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers 2 potent “in-tumour” chemotherapy to Pancreatic Ductal Adenocarcinoma. British Journal of Cancer (10.1038/s41416-024-02869-3)
• de Paula do Nascimento, R. et al. 2024. Myrciaria jaboticaba fruit peel: Bioactive composition as determined by distinct harvest seasons and in vitro anti-cancer activity. Plants 13(20), article number: 2907. (10.3390/plants13202907)
• Hill, L. 2024. Unravelling the early responses to KrasG12D activation in the adult lung epithelium. PhD Thesis, Cardiff University.
• Lovatt, C. et al. 2024. Pigment epithelium derived factor drives melanocyte proliferation and migration in neurofibromatosis café au lait macules. Skin Health and Disease 4(5), article number: e394. (10.1002/ski2.394)
• Padilha, A., Jones, E., Cutting, S., Godkin, A., Gallimore, A. and Parry, L. 2024. Regulatory T Cells play a role in determining the tumourigenicity of the Intestinal Stem Cell Niche. Gastro Hep Advances (10.1016/j.gastha.2024.09.014)
• Seaton, G., Smith, H., Brancale, A., Westwell, A. D. and Clarkson, R. 2024. Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age. Molecular Cancer 23(1), article number: 7. (10.1186/s12943-023-01922-8)
• Tornillo, G., Warrington, L., Kendrick, H., Higgins, A. T., Hay, T., Beck, S. and Smalley, M. J. 2024. Conditional in vivo deletion of LYN kinase has little effect on a BRCA1 loss-of-function-associated mammary tumour model. Disease Models and Mechanisms 17(1), article number: dmm050211. (10.1242/dmm.050211)
• Vaiasicca, S. et al. 2024. Transcriptomic analysis reveals the anti-cancer effect of gestational mesenchymal stem cell secretome. Stem Cells Translational Medicine 13(7), pp. 693-710. (10.1093/stcltm/szae024)

2023

• Almotiri, A., Boyd, A. S. and Rodrigues, N. P. 2023. Zeb1 Regulates the function of lympho-myeloid primed progenitors after transplantation. Biomolecules 13(9), article number: 1386. (10.3390/biom13091386)
• Alshahrany, N., Begum, A., Siebzehnrubl, D., Jimenez-Pascual, A. and Siebzehnrubl, F. A. 2023. Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion. Cancer Letters 571, article number: 216349. (10.1016/j.canlet.2023.216349)
• Arana Echarri, A., Struszczak, L., Beresford, M., Campbell, J. P., Jones, R. H., Thompson, D. and Turner, J. E. 2023. Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study. Frontiers in Physiology 14, article number: 1107070. (10.3389/fphys.2023.1107070)
• Bates, E. A., Lovatt, C., Plein, A. R., Davies, J. A., Siebzehnrubl, F. A. and Parker, A. L. 2023. Engineering adenoviral vectors with improved GBM selectivity. Viruses 15(5), article number: 1086. (10.3390/v15051086)
• Brown, J. et al. 2023. A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance. Biochemical Pharmacology 208, article number: 115410. (10.1016/j.bcp.2023.115410)
• Chan, Y. et al. 2023. (+)-catechin attenuates multiple atherosclerosis-associated processes in vitro, modulates disease-associated risk factors in C57BL/6J mice and reduces atherogenesis in LDL receptor deficient mice by inhibiting inflammation and increasing markers of plaque stability. Molecular Nutrition & Food Research 67(14), article number: 2200716. (10.1002/mnfr.202200716)
• Edmunds, G., Beck, S., Umakant Kale, K., Spasic, I., O'Neill, D., Brodbelt, D. and Smalley, M. J. 2023. Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. Journal of Mammary Gland Biology and Neoplasia 28(6) (10.1007/s10911-023-09531-3)
• Jones, R. et al. 2023. A Phase I/II trial of Oral SRA737 (a Chk1 Inhibitor) given in combination with low-dose gemcitabine in patients with advanced cancer. Clinical Cancer Research 29(2), pp. 331-340. (10.1158/1078-0432.CCR-22-2074)
• Kristeleit, R. et al. 2023. A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer. British Journal of Cancer (10.1038/s41416-023-02279-x)
• Michael, D. R., Kerry-Smith, J., Webberley, T. S., Murphy, K., Plummer, S. F., Parry, L. and Marchesi, J. R. 2023. Does flow culture impact upon gut-probiotic interactions: a comparison with static culture. Journal of Functional Foods 104, article number: 105519. (10.1016/j.jff.2023.105519)
• Moore, J. W., Dale, T. C. and Woolley, T. E. 2023. Modelling polarity-driven laminar patterns in bilayer tissues with mixed signalling mechanisms. SIAM Journal on Applied Dynamical Systems 22(4), pp. 2945-2990. (10.1137/22M1522565)
• Ordonez, L., Tornillo, G., Kendrick, H., Hay, T. and Smalley, M. J. 2023. NOTCH and AKT signalling interact to drive mammary tumour heterogeneity. Cancers 15(17), article number: 4324. (10.3390/cancers15174324)
• Rastogi, N. et al. 2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37, pp. 276-287. (10.1038/s41375-022-01801-z)
• Sanz-Castillo, B. et al. 2023. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. The EMBO Journal 42(2), article number: e110833. (10.15252/embj.2022110833)
• Shorning, B., Trent, N., Griffiths, D. F., Worzfeld, T., Offermanns, S., Smalley, M. J. and Williamson, M. 2023. Plexin-B1 mutation drives metastasis in prostate cancer mouse models. Cancer Research Communications 3(3), pp. 444-458. (10.1158/2767-9764.CRC-22-0480)
• Singh, N., Siebzehnrubl, F. A. and Martinez Garay, I. 2023. Transcriptional control of embryonic and adult neural progenitor activity. Frontiers in Neuroscience 17, article number: 1217596. (10.3389/fnins.2023.1217596)
• Varney, D. et al. 2023. Epidemiology of mammary tumours in bitches under veterinary care in the UK in 2016. Veterinary Record 193(5), article number: e3054. (10.1002/vetr.3054)

2022

• Almotiri, A., Abdelfattah, A. and Rodrigues, N. P. 2022. Flow cytometry analysis of hematopoietic stem/progenitor cells and mature blood cell subsets in atherosclerosis. In: Ramji, D. ed. Atherosclerosis., Vol. 2419. Methods in Molecular Biology Springer, pp. 583-595., (10.1007/978-1-0716-1924-7_36)
• Anjos-Afonso, F. et al. 2022. Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population. Nature Communications 13, article number: 2048. (10.1038/s41467-022-29675-w)
• Banerjee, S. et al. 2022. A phase I trial of CT900, a novel α-folate receptor-mediated thymidylate synthase inhibitor, with expansion cohorts in patients with high grade serous ovarian cancer. Clinical Cancer Research 22, article number: 1268. (10.1158/1078-0432.CCR-22-1268)
• Bates, E. A. et al. 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25, pp. 43-56. (10.1016/j.omto.2022.03.007)
• D'Ambrogio, J., Hill, L. and Hogan, C. 2022. Cell competition: Clonal competition protects against early tumorigenesis. Current Biology 32(1), pp. PR52-R54. (10.1016/j.cub.2021.11.029)
• Dimitriou, P., Li, J., Tornillo, G., Smalley, M. and Barrow, D. 2022. Droplet incubator: a new droplet-based model to investigate living cell-synthetic cell interactions. Presented at: MicroTAS 2022, Hangzhou, China, 23-27 October 2022.
• Engel, R. M. et al. 2022. Modeling colorectal cancer: A bio-resource of 50 patient-derived organoid lines. Journal of Gastroenterology and Hepatology 37(5), pp. 898-907. (10.1111/jgh.15818)
• Hidalgo, M. et al. 2022. A preclinical and phase Ib study of palbociclib plus nab-paclitaxel in patients with metastatic adenocarcinoma of the pancreas. Cancer Research Communications 2(11), pp. 1326–1333. (10.1158/2767-9764.CRC-22-0072)
• Howell, S. J. et al. 2022. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial. The Lancet Oncology 23(7), pp. 851-864. (10.1016/s1470-2045(22)00284-4)
• Koushyar, S., Meniel, V. S., Phesse, T. J. and Pearson, H. B. 2022. Exploring the Wnt pathway as a therapeutic target for prostate cancer. Biomolecules 12(2), article number: 309. (10.3390/biom12020309)
• May, S. et al. 2022. Modification of diet to reduce the stemness and tumourigenicity of murine and human intestinal cells. Molecular Nutrition & Food Research 66(19), article number: 2200234. (10.1002/mnfr.202200234)
• Menendez-Gonzalez, J. B., Strange, K. E., Bassetto, M., Brancale, A., Rodrigues, N. P. and Ferla, S. 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2, article number: 1013229. (10.3389/fddsv.2022.1013229)
• Menendez-Gonzalez, J. B. and Rodrigues, N. P. 2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. In: Ramji, D. ed. Atherosclerosis., Vol. 2419. Methods in Molecular Biology Springer, pp. 73-88., (10.1007/978-1-0716-1924-7_5)
• Moore, J. W., Dale, T. C. and Woolley, T. E. 2022. Polarity driven laminar pattern formation by lateral-inhibition in 2D and 3D bilayer geometries. IMA Journal of Applied Mathematics 87(4), pp. 568-606.
• Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
• Owen, J. S., Clayton, A. and Pearson, H. B. 2022. Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer. Biomolecules 13(1), article number: 67. (10.3390/biom13010067)
• Parry, L. 2022. Stemming the flow toward disease: A research profile of Lee Parry. eFood 3(6), article number: e46. (10.1002/efd2.46)
• Petrik, D., Jorgensen, S., Eftychidis, V. and Siebzehnrubl, F. A. 2022. Singular adult neural stem cells do not exist. Cells 11(4), article number: 722. (10.3390/cells11040722)
• Routledge, D. et al. 2022. The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer. eLife 11, article number: e77376. (10.7554/elife.77376)
• Saad, F. et al. 2022. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. The Lancet Oncology 23(10), pp. 1297-1307. (10.1016/S1470-2045(22)00498-3)
• Siebzehnrubl, F. A. 2022. Isolating and culturing of precursor cells from the adult human brain. In: Deleyrolle, L. P. ed. Neural Progenitor Cells: Methods and Protocols., Vol. 2389. Methods in Molecular Biology New York, NY: Springer, pp. 95-102., (10.1007/978-1-0716-1783-0_9)
• Williams, N. G. and Parry, L. 2022. Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?. eFood 3(6), article number: e45. (10.1002/efd2.45)
• Woolley, T., Hill, W. and Hogan, C. 2022. Accounting for dimensional differences in stochastic domain invasion with applications to precancerous cell removal. Journal of Theoretical Biology 541, article number: 111024. (10.1016/j.jtbi.2022.111024)

2021

• Abdelfattah, A. M. et al. 2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 5(20), pp. 4285-4290. (10.1182/bloodadvances.2021004726)
• Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131(1), article number: e129115. (10.1172/JCI129115)
• Arana Echarri, A. et al. 2021. A phenomic perspective on factors influencing breast cancer treatment: integrating aging and lifestyle in blood and tissue biomarker profiling. Frontiers in Immunology 11, article number: 616188. (10.3389/fimmu.2020.616188)
• Castro, J. et al. 2021. A nuclear-directed ribonuclease variant targets cancer stem cells and inhibits migration and invasion of breast cancer cells. Cancers 13(17), article number: 4350. (10.3390/cancers13174350)
• Davies, J. A. et al. 2021. Efficient intravenous tumor targeting using the αvβ6 integrin-selective precision virotherapy Ad5NULL-A20. Viruses 13(5), article number: 864. (10.3390/v13050864)
• Dimitriou, P., Li, J., Tornillo, G., McCloy, T. and Barrow, D. 2021. Droplet microfluidics for tumor drug-related studies and programmable artificial cells. Global Challenges 5(7), article number: 2000123. (10.1002/gch2.202000123)
• Edmunds, G. L. et al. 2021. Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study. Canine Medicine and Genetics 8, article number: 2. (10.1186/s40575-021-00100-7)
• Gupta, B. et al. 2021. The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus. Cell Reports 36(8), article number: 109588. (10.1016/j.celrep.2021.109588)
• Hill, W. et al. 2021. EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neigbors in the adult pancreas. Current Biology 31(12), pp. 2550-2560., article number: E5. (10.1016/j.cub.2021.03.094)
• Jukes, Z. et al. 2021. Lipid profiling of mouse intestinal organoids for studying APC mutations. Bioscience Reports 41(3), article number: BSR20202915. (10.1042/BSR20202915)
• Kermanizadeh, A., Jacobsen, N. R., Murphy, F., Parry, L., Zhang, H. and Møller, P. 2021. A review of the current state of nanomedicines for targeting and treatment of cancers - achievements and future challenges. Advanced Therapeutics 4(2), article number: 2000186. (10.1002/adtp.202000186)
• Lawson, H. et al. 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5(3), pp. 889-899. (10.1182/bloodadvances.2020002702)
• Lawson, H. et al. 2021. CITED2 coordinates key haematopoietic regulatory pathways to maintain the HSC pool in both steady-state haematopoiesis and transplantation. Stem Cell Reports 16(11), pp. 2784-2797. (10.1016/j.stemcr.2021.10.001)
• Mian, S. A., Dos Anjos-Afonso, F. and Bonnet, D. 2021. Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy. Frontiers in Immunology 11, article number: 619236. (10.3389/fimmu.2020.619236)
• Moore, J. W., Lau, Z., Kaouri, K., Dale, T. C. and Woolley, T. E. 2021. A general computational framework for COVID-19 modelling with applications to testing varied interventions in education environments. COVID 1(4), pp. 674-703. (10.3390/covid1040055)
• Moss, J. W. E. et al. 2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12(8), pp. 3657-3671. (10.1039/D0FO02867C)
• O'Morain, V. L. et al. 2021. The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes. Molecular Nutrition & Food Research 65(17), article number: 2100214. (10.1002/mnfr.202100214)
• Ordonez, L. D. et al. 2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14(5), article number: dmm048736. (10.1242/dmm.048736)
• Pope, I. et al. 2021. Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy. Analyst 146(7), pp. 2277-2291. (10.1039/D0AN02381G)
• Rastogi, N. et al. 2021. Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo. British Journal of Haematology 193(1), pp. 155-159. (10.1111/bjh.17125)
• Seligmann, J. F. et al. 2021. Inhibition of WEE1 is effective in TP53- and RAS-mutant metastatic colorectal cancer: a randomized trial (FOCUS4-C) comparing adavosertib (AZD1775) with active monitoring. Journal of Clinical Oncology 39(33), pp. 3705-3715. (10.1200/JCO.21.01435)
• Soukupova, J. et al. 2021. The discovery of a novel anti-metastatic Bcl3 inhibitor. Molecular Cancer Therapeutics 10(5), pp. 775-786. (10.1158/1535-7163.MCT-20-0283)
• Stott, K. J., Phillips, B., Parry, L. and May, S. 2021. Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer. Bioscience Reports 41(7), article number: BSR20204113. (10.1042/BSR20204113)
• Tran, B. M., Flanagan, D. J., Phesse, T. J., Vincan, E. and Phesse, T. 2021. Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways during developmental morphogenesis: implications for therapeutic targeting in colorectal cancer. In: Handbook of Experimental Pharmacology.

2020

• Adams-Smith, R., Colmont, C., Mukhtar, A., Morgan, H. and Patel, G. K. 2020. A novel oncostatin M/interleukin-31 receptor mutation in familial primary localized cutaneous amyloidosis. Clinical and Experimental Dermatology 45(2), pp. 254-256. (10.1111/ced.14059)
• Alanazi, B. et al. 2020. Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia. Leukemia 34(2), pp. 427-440. (10.1038/s41375-019-0596-4)
• Badder, L. M. et al. 2020. 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors. PLoS ONE 15(8), article number: e0235319. (10.1371/journal.pone.0235319)
• Badr, C. E., Silver, D. J., Siebzehnrubl, F. A. and Deleyrolle, L. P. 2020. Metabolic heterogeneity and adaptability in brain tumors. Cellular and Molecular Life Sciences 77, pp. 5101-5119. (10.1007/s00018-020-03569-w)
• Caye, A. et al. 2020. Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment. Leukemia 34, pp. 1658-1668. (10.1038/s41375-019-0662-y)
• Hong, D. S. et al. 2020. Tisotumab vedotin in previously treated recurrent or metastatic cervical cancer. Clinical Cancer Research 26(6), pp. 1220-1228. (10.1158/1078-0432.CCR-19-2962)
• Jardé, T. et al. 2020. Mesenchymal niche-derived neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium. Cell Stem Cell 27(4), pp. 646-662.E7., article number: VOLUME 27, ISSUE 4, P646-662.E7, OCTOBER 01, 2020. (10.1016/j.stem.2020.06.021)
• Jimenez-Pascual, A., Mitchell, K., Siebzehnrubl, F. A. and Lathia, J. D. 2020. FGF2: a novel druggable target for glioblastoma?. Expert Opinion on Therapeutic Targets 24(4), pp. 311-318. (10.1080/14728222.2020.1736558)
• Jones, R. H. et al. 2020. Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive breast cancer (FAKTION): a multicentre, randomised, controlled, phase 2 trial. Lancet Oncology 21(3), pp. 345-347. (10.1016/S1470-2045(19)30817-4)
• Kiraga, L. et al. 2020. Biodistribution PET/CT study of hemoglobin-DFO-89Zr complex in healthy and lung tumor-bearing mice. International Journal of Molecular Sciences 21(14), article number: 4991. (10.3390/ijms21144991)
• Koushyar, S., Powell, A. G., Vincan, E. and Phesse, T. J. 2020. Targeting Wnt signaling for the treatment of gastric cancer. International Journal of Molecular Sciences 21(11), article number: 3927. (10.3390/ijms21113927)
• May, S., McDermott, G., Marchesi, J. and Parry, L. 2020. Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome. Journal of Berry Research 10(1), pp. 61-76. (10.3233/JBR-180372)
• May, S., Parry, C. and Parry, L. 2020. Berry chemoprevention: do berries decrease the window of opportunity for tumourigenesis. Food Frontiers 1(3) (10.1002/fft2.32)
• Morgan, H. J. et al. 2020. Human basal cell carcinoma: the induction of anagen hair follicle differentiation. Clinical and Experimental Dermatology 45(3), pp. 309-317. (10.1111/ced.14108)
• Peltola, K. J. et al. 2020. ODM-204, a novel dual Inhibitor of CYP17A1 and androgen receptor: early results from phase I dose escalation in men with castration-resistant prostate cancer. European Urology Focus 6(1), pp. 63-70. (10.1016/j.euf.2018.08.022)
• Pires, A. et al. 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8(12), pp. 1520 - 1531. (10.1158/2326-6066.CIR-20-0070)
• Queiroz, C. J. et al. 2020. NAP1L1: a novel human colorectal cancer biomarker derived from animal models of Apc inactivation. Frontiers in Oncology 10, article number: 1565. (10.3389/fonc.2020.01565)
• Regan, J. L. and Smalley, M. J. 2020. Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies. NPJ Breast Cancer 6, article number: 32. (10.1038/s41523-020-00175-8)
• Robinson, A. J. et al. 2020. Reactive oxygen species drive proliferation in acute myeloid leukemia via the glycolytic regulator PFKFB3. Cancer Research 80(5), pp. 937-949. (10.1158/0008-5472.CAN-19-1920)
• Salvador, B. et al. 2020. CDK4/6 inhibitors impair recovery from cytotoxic chemotherapy in pancreatic adenocarcinoma. Cancer Cell 37(3), pp. 340-353. (10.1016/j.ccell.2020.01.007)
• Scholz, N., Kurian, K. M., Siebzehnrubl, F. A. and Licchesi, J. D. F. 2020. Targeting the ubiquitin system in glioblastoma. Frontiers in Oncology 10, article number: 574011. (10.3389/fonc.2020.574011)
• Shorning, B. Y., Dass, M. S., Smalley, M. J. and Pearson, H. B. 2020. The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling. International Journal of Molecular Sciences 21(12), article number: 4507. (10.3390/ijms21124507)
• Tran, B. M. et al. 2020. The hepatitis B virus pre-core protein p22 activates Wnt sgnaling. Cancers 12(6), article number: 1435. (10.3390/cancers12061435)
• Turnham, D. J., Bullock, N., Dass, M. S., Staffurth, J. N. and Pearson, H. B. 2020. The PTEN conundrum: how to target PTEN-deficient prostate cancer. Cells 9(11), article number: 2342. (10.3390/cells9112342)
• Turnham, D. J., Yang, W. W., Davies, J., Varnava, A., Ridley, A. J., Conlan, R. S. and Clarkson, R. W. E. 2020. Bcl-3 promotes multi-modal tumour cell migration via NF-kB1 mediated regulation of Cdc42. Carcinogenesis 41(10), pp. 1432-1443. (10.1093/carcin/bgaa005)
• Valle-Encinas, E. and Dale, T. C. 2020. Wnt ligand and receptor patterning in the liver. Current Opinion in Cell Biology 62, pp. 17-25. (10.1016/j.ceb.2019.07.014)

2019

• de Bono, J. S. et al. 2019. Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial. Lancet Oncology 20(3), pp. 383-393. (10.1016/S1470-2045(18)30859-3)
• Eissman, M. F. et al. 2019. IL-33 mediated mast cell activation promotes gastric cancer through macrophage mobilization. Nature Communications 10, article number: 2735. (10.1038/s41467-019-10676-1)
• Flanagan, D., Barker, N., Ernst, M., Vincan, E. and Phesse, T. 2019. The function of Lgr5+ cells in the gastric antrum does not require Fzd7 or Myc in vivo. Biomedicines 7(3), article number: 50. (10.3390/biomedicines7030050)
• Flanagan, D. J. et al. 2019. Frizzled-7 is required for Wnt signaling in gastric tumours with and without Apc mutations. Cancer Research 79(5), pp. 970-981. (10.1158/0008-5472.CAN-18-2095)
• Flanagan, D. J., Vincan, E. and Phesse, T. J. 2019. Wnt signaling in cancer: not a binary ON:OFF switch. Cancer Research (10.1158/0008-5472.CAN-19-1362)
• French, R. and Tornillo, G. 2019. Heterogeneity of mammary stem cells. Advances in Experimental Medicine and Biology 1169, pp. 119-140. (10.1007/978-3-030-24108-7_7)
• Healey, G. D. et al. 2019. Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. Journal for ImmunoTherapy of Cancer 7(1), article number: 280. (10.1186/s40425-019-0765-z)
• Hill, W. and Hogan, C. 2019. Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level. Small GTPases 10(4), pp. 305-310. (10.1080/21541248.2017.1324940)
• Jimenez-Pascual, A., Lathia, J. D. and Siebzehnrubl, F. A. 2019. ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells. Molecular & Cellular Oncology 7(1), article number: 1684787. (10.1080/23723556.2019.1684787)
• Jimenez-Pascual, A. et al. 2019. ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells. Cancer Discovery 9(11), pp. 1574-1589. (10.1158/2159-8290.CD-18-1308)
• Jimenez-Pascual, A. and Siebzehnrubl, F. A. 2019. Fibroblast growth factor receptor functions in glioblastoma. Cells 8(7), article number: 715. (10.3390/cells8070715)
• Kannen, V., Parry, L. and Martin, F. L. 2019. Phages enter the fight against colorectal cancer. Trends in Cancer 5(10), pp. 577-579. (10.1016/j.trecan.2019.08.002)
• Legge, D. N. et al. 2019. BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells. Disease Models and Mechanisms 12(3), article number: 37697. (10.1242/dmm.037697)
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• Mohamed, N., Hay, T., Reed, K. R., Smalley, M. J. and Clarke, A. R. 2019. APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression. BMC Cancer 19, article number: 677. (10.1186/s12885-019-5867-y)
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• Parry, L. and Phesse, T. J. 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3(12) (10.21037/biotarget.2019.07.01)
• Young, M. A., May, S., Damo, A., Yoon, Y. S., Hur, M., Swat, W. and Parry, L. 2019. Epigenetic regulation of Dlg1, via Kaiso, alters mitotic spindle polarity and promotes intestinal tumourigenesis. Molecular Cancer Research 17(3), pp. 686-696. (10.1158/1541-7786.MCR-18-0280)
• Young, R. M., Ewan, K. B., Ferrer, V. P., Allende, M. L., Godovac-Zimmermann, J., Dale, T. C. and Wilson, S. W. 2019. Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation. eLife 8, article number: e51447. (10.7554/eLife.51447)

2018

• Basu, B. et al. 2018. Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. Annals of Oncology 29(9), pp. 1918-1925. (10.1093/annonc/mdy245)
• Borgogna, C. et al. 2018. β-HPV infection correlates with early stages of carcinogenesis in skin tumors and patient-derived xenografts from a kidney transplant recipient cohort. Frontiers in Microbiology 9, article number: 117. (10.3389/fmicb.2018.00117)
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• Burke, Z. D., Reed, K. R., Yeh, S., Meniel, V. S., Sansom, O. J., Clarke, A. R. and Tosh, D. 2018. Spatiotemporal regulation of liver development by the Wnt/β- catenin pathway. Scientific Reports 8, article number: 2735. (10.1038/s41598-018-20888-y)
• Clarke, N. et al. 2018. Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncology 19(7), pp. 975-986. (10.1016/S1470-2045(18)30365-6)
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• Hill, W. 2018. Heterotypic cell-cell interactions between KrasG12D cells and normal neighbours in early pancreatic cancer. PhD Thesis, Cardiff University.
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• Lopez-Millan, B. et al. 2018. IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML. OncoImmunology 7(9), article number: e1477460. (10.1080/2162402X.2018.1477460)
• May, S. et al. 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology 245(3), pp. 270-282. (10.1002/path.5074)
• Morgan, H. 2018. Elucidating the role of TGFβ signalling in drug resistant Hh driven cancers. PhD Thesis, Cardiff University.
• Olivero, C., Lanfredini, S., Borgogna, C., Gariglio, M. and Patel, G. K. 2018. HPV-induced field cancerisation: Transformation of adult tissue stem cell into cancer stem cell. Frontiers in Microbiology 9, article number: 546. (10.3389/fmicb.2018.00546)
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• Prim Padilha, A. 2018. Molecular and functional characterization of the role of Foxp3+ regulatory T (Treg) cells in the development of intestinal cancer. PhD Thesis, Cardiff University.
• Puig Barbe, A. 2018. A network of bHLH factors controls self-renewal and bipotential differentiation in the Drosophila intestine. PhD Thesis, Cardiff University.
• Siebzehnrubl, F. A. et al. 2018. Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition. Proceedings of the National Academy of Sciences 115(37), pp. E8765-E8774. (10.1073/pnas.1807962115)
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2017

• Badder, L. 2017. Developing stem-cell containing organoids as a pre-clinical model for colorectal cancer therapeutics. PhD Thesis, Cardiff University.
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• Colbeck, E. J. et al. 2017. Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction. Cancer Immunology Research 5(11), pp. 1005-1015. (10.1158/2326-6066.CIR-17-0131)
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• Flanagan, D. J., Barker, N., Nowell, C., Clevers, H., Ernst, M., Phesse, T. J. and Vincan, E. 2017. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models and Mechanisms 10(8), pp. 971-980. (10.1242/dmm.029876)
• Garcia Martin, I., Janssen, A., Jones, R., Grimstead, J. W., Penketh, R. J. A., Baird, D. M. and John, R. M. 2017. Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis. Placenta 59, pp. 61-68. (10.1016/j.placenta.2017.09.007)
• Guitart, A. V. et al. 2017. Fumarate hydratase is a critical regulator of hematopoietic stem cell functions. Journal of Experimental Medicine 214(3), pp. -., article number: 719. (10.1084/jem.20161087)
• Helft, J., Anjos-Afonso, F., van der Veen, A. G., Chakravarty, P., Bonnet, D. and Reis e Sousa, C. 2017. Dendritic cell lineage potential in human early hematopoietic progenitors. Cell Reports 20(3), pp. 529-537. (10.1016/j.celrep.2017.06.075)
• Hwang, H. S., Parfitt, G. J., Brown, D. J. and Jester, J. V. 2017. Meibocyte differentiation and renewal: Insights into novel mechanisms of meibomian gland dysfunction (MGD). Experimental Eye Research 163, pp. 37-45. (10.1016/j.exer.2017.02.008)
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• Kay, S. K. et al. 2017. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt. PLoS Computational Biology 13(2), article number: e1005400. (10.1371/journal.pcbi.1005400)
• Konstantinou, M. 2017. Characterising In-111-anti-γH2AX-TAT in targeting the DNA damage signal associated with Wnt activated colorectal cancer. PhD Thesis, Cardiff University.
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• Lanfredini, S. et al. 2017. HPV8 field cancerization in a transgenic mouse model is due to Lrig1+Keratinocyte stem cell expansion. Journal of Investigative Dermatology 137(10), pp. 2208-2216. (10.1016/j.jid.2017.04.039)
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• Martin, A. C. B. et al. 2017. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget 8(42), pp. 72260-72271. (10.18632/oncotarget.20139)
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• Menendez Gonzalez, J. B. 2017. Exploring the role of GATA2 in normal and malignant haematopoiesis. PhD Thesis, Cardiff University.
• Mohamed, N. 2017. Characterizing the roles of APC2 protein in ovarian homeostasis and tumourigenesis. PhD Thesis, Cardiff University.
• Phesse, T. J. and Sansom, O. J. 2017. Lgr5 joins the club of gastric stem cell markers in the corpus. Nature Cell Biology 19(7), pp. 752-754. (10.1038/ncb3567)
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• Roy, A. et al. 2017. Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression. Oncotarget 8, pp. 24815-24827. (10.18632/oncotarget.15820)
• Schwab, R. . H., Amin, N., Flanagan, D. J., Johanson, T. M., Phesse, T. and Vincan, E. 2017. Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells. Developmental Dynamics 247(3), pp. 521-530. (10.1002/dvdy.24527)
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• Tang, H. K. C., Lee, D. Y. H., Thompson, I., Ingram, J. R., Stone, N. and Patel, G. . K. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23(6), pp. 747-749. (10.1111/tbj.12910)
• Yeo, S. K., French, R., Filomena, S. and Clarkson, R. 2017. Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells. Breast Cancer Research and Treatment 162(3), pp. 465-477. (10.1007/s10549-017-4149-0)

2016

• Abraham, T. et al. 2016. Ellipsoid segmentation model for analyzing light-attenuated 3D confocal image stacks of fluorescent multi-cellular spheroids. PLoS ONE 11(6), article number: e0156942. (10.1371/journal.pone.0156942)
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• Denoyer, D. et al. 2016. Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution. Oncotarget 7(24), pp. 37064-37080. (10.18632/oncotarget.9245)
• Estrada, M. F. et al. 2016. Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression. Biomaterials 78, pp. 50-61. (10.1016/j.biomaterials.2015.11.030)
• Fang, H. Y., Martinez-Arias, A. and De Navascues Melero, J. 2016. Autocrine and paracrine Wingless signalling in the Drosophila midgut by both continuous gradient and asynchronous bursts of wingless expression. F1000Research 5, article number: 317. (10.12688/f1000research.8170.1)
• Flanagan, D. J., Schwab, R. H. M., Tran, B. M., Phesse, T. J. and Vincan, E. 2016. Isolation and culture of adult intestinal, gastric, and lver organoids for cre-recombinase-mediated gene deletion. In: Methods in Molecular Biology. Humana Press, pp. 1-11., (10.1007/7651_2016_14)
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• Jurado, J., De Navascues Melero, J. and Gorfinkiel, N. 2016. α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Journal of Cell Science, article number: jcs.193268. (10.1242/jcs.193268)
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• Turingan, R. S., Vasantgadkar, S., Palombo, L., Hogan, C., Jiang, H., Tan, E. and Selden, R. F. 2016. Rapid DNA analysis for automated processing and interpretation of low DNA content samples. Investigative Genetics 7(1), article number: 2. (10.1186/s13323-016-0033-7)
• Yeo, S. K., Ali, A. Y., Hayward, O. A., Turnham, D., Jackson, T., Bowen, I. D. and Clarkson, R. 2016. Bisabolene, a sesquiterpene from the essential oil extract of opoponax (Commiphora guidottii), exhibits cytotoxicity in breast cancer cell lines. Phytotherapy Research 30(3), pp. 418-425. (10.1002/ptr.5543)
• Zhao, C. et al. 2016. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications 7, article number: 10883. (10.1038/ncomms10883)

2015

• Ali, A. Y. et al. 2015. Anti-metastatic and cytotoxic properties of frankincense and scented myrrh. Anticancer Research 35(7), pp. 4310-4311.
• Costello, P., Sargent, M., Maurice, D., Esnault, C., Foster, K., Anjos-Afonso, F. and Treisman, R. 2015. MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development. Blood 125(8), pp. 1244-1255. (10.1182/blood-2014-08-595603)
• Dale, T. et al. 2015. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nature Chemical Biology 11, pp. 973-980. (10.1038/nchembio.1952)
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• Flanagan, D. et al. 2015. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5+ stem cells. Stem Cell Reports 4(5), pp. 759-767. (10.1016/j.stemcr.2015.03.003)
• Foster, K., Lassailly, F., Anjos-Afonso, F., Currie, E., Rouault-Pierre, K. and Bonnet, D. 2015. Different motile behaviors of human hematopoietic stem versus progenitor cells at the osteoblastic niche. Stem Cell Reports 5(5), pp. 690-701. (10.1016/j.stemcr.2015.09.003)
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• French, R., Hayward, O., Jones, S., Yang, W. and Clarkson, R. 2015. Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL. Molecular Cancer 14, article number: 209. (10.1186/s12943-015-0478-y)
• Greenow, K. R. and Smalley, M. J. 2015. Overview of genetically engineered mouse models of breast cancer used in translational biology and drug development. Current Protocols in Pharmacology 70(1), article number: 70:14.36.1-14.36.14. (10.1002/0471141755.ph1436s70)
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• Leal, M. d. P. C., Sciortino, M., Tornillo, G., Colombo, S., Defilippi, P. and Cabodi, S. 2015. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Gene 562(1), pp. 1-7. (10.1016/j.gene.2015.02.027)
• Lio, K. I. 2015. Characterising the role of Cbx3/HP1γ in normal intestinal homeostasis and tumourigenesis. PhD Thesis, Cardiff University.
• Mallinger, A. et al. 2015. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. Journal of Medicinal Chemistry 58(4), pp. 1717-1735. (10.1021/jm501436m)
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• Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
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• Reed, K. R. et al. 2015. Correction for Reed et al., B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 112(10), pp. E1168. (10.1073/pnas.1502294112)
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• Sampurno, S., Cross, R., Pearson, H., Kaur, P., Malaterre, J. and Ramsay, R. G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33(2), pp. 102-112. (10.3109/08977194.2015.1016222)
• Siebzehnrubl, F. 2015. Application of an RNA amplification method for reliable single-cell transcriptome analysis. Biotechniques 59(3), pp. 137-148. (10.2144/000114331)
• Soady, K. J. et al. 2015. Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Breast Cancer Research 17, article number: 31. (10.1186/s13058-015-0539-6)
• Takizawa, I. et al. 2015. Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity. Oncotarget 6(2), pp. 604-616. (10.18632/oncotarget.2820)
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2014

• Anjos-Afonso, F. and Bonnet, D. 2014. Forgotten gems. Cell Cycle 13(4), pp. 503-504. (10.4161/cc.27788)
• Carotenuto, M. et al. 2014. H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC. Oncotarget 5(14), pp. 5736-5749. (10.18632/oncotarget.2169)
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• Davies, E. J., Marsh Durban, V., Meniel, V., Williams, G. T. and Clarke, A. R. 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233(1), pp. 27-38. (10.1002/path.4312)
• de Groot, R. E. A. et al. 2014. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Science Signaling 7(317), article number: ra26. (10.1126/scisignal.2004985)
• DiTommaso, T., Cottle, D. L., Pearson, H. B., Schlüter, H., Kaur, P., Humbert, P. O. and Smyth, I. M. 2014. Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genetics 10(10), article number: e1004706. (10.1371/journal.pgen.1004706)
• Elsum, I. A. et al. 2014. Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. Oncogene 33(48), pp. 5523-5533. (10.1038/onc.2013.498)
• Fizazi, K. et al. 2014. Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial. Lancet Oncology 15(9), pp. 975-985. (10.1016/S1470-2045(14)70240-2)
• Godde, N. J. et al. 2014. Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genetics 10(5), article number: e1004323. (10.1371/journal.pgen.1004323)
• Gödde, N. J., Pearson, H. B., Smith, L. K. and Humbert, P. O. 2014. Dissecting the role of polarity regulators in cancer through the use of mouse models. Experimental Cell Research 328(2), pp. 249-257. (10.1016/j.yexcr.2014.08.036)
• Greenow, K. R., Clarke, A. R., Williams, G. T. and Jones, R. 2014. Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33, pp. 4089-4096. (10.1038/onc.2013.371)
• Griessinger, E. et al. 2014. A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: A new tool to decipher their chemoresistance and self-renewal mechanisms. Stem Cells Translational Medicine 3(4), pp. 520-529. (10.5966/sctm.2013-0166)
• Hare, L. et al. 2014. Physiological expression of the PI3K-activating mutationPik3caH1047Rcombines withApcloss to promote development of invasive intestinal adenocarcinomas in mice. Biochemical Journal 458(2), pp. 251-258. (10.1042/BJ20131412)
• Hickman, J. A. et al. 2014. Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo. Biotechnology Journal 9(9), pp. 1115-1128. (10.1002/biot.201300492)
• Holik, A. Z., Young, M., Krzystyniak, J., Williams, G. T., Metzger, D., Shorning, B. Y. and Clarke, A. R. 2014. Brg1 loss attenuates aberrant Wnt-signalling and prevents Wnt-dependent tumourigenesis in the murine small intestine. PLoS Genetics 10(7), article number: e1004453. (10.1371/journal.pgen.1004453)
• Infantino, S. et al. 2014. The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice. Science Signaling 7(338), pp. ra77. (10.1126/scisignal.2005105)
• Khurana, R. et al. 2014. OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer. BMC Bioinformatics 15(1), pp. 15. (10.1186/1471-2105-15-15)
• Koh, D. -. et al. 2014. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences of the United States of America 111(42), pp. 15078-15083. (10.1073/pnas.1318780111)
• Krzystyniak, J. 2014. Epigenetic modulation of intestinal homeostasis and tumorigenesis by Brm SWI/SNF chromatin remodelling factor. PhD Thesis, Cardiff University.
• Marsh Durban, V., Jansen, M., Davies, E. J., Morsink, F. H., Offerhaus, G. J. A. and Clarke, A. R. 2014. Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. American Journal of Pathology 184(1), pp. 86-91. (10.1016/j.ajpath.2013.10.003)
• Melchor, L. et al. 2014. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. Journal of Pathology 233(2), pp. 124-137. (10.1002/path.4345)
• Phesse, T. J. et al. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 21(6), pp. 956-966. (10.1038/cdd.2014.15)
• Phesse, T. J. et al. 2014. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration. Science Signaling 7(345), article number: ra92. (10.1126/scisignal.2005411)
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• Rudge, F. and Dale, T. C. 2014. Therapeutic targeting of the Wnt signaling network. In: Hoppler, S. P. and Moon, R. T. eds. Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons, pp. 421-443.
• Sarkisian, M. R. et al. 2014. Detection of primary cilia in human glioblastoma. Journal of Neuro-Oncology 117(1), pp. 15-24. (10.1007/s11060-013-1340-y)
• Stuart, E. et al. 2014. Therapeutic inhibition of jak activity inhibits progression of gastrointestinal tumors in mice. Molecular Cancer Therapeutics 13(2), pp. 468. (10.1158/1535-7163.MCT-13-0583-T)
• Suhalim, J. L. et al. 2014. Effect of desiccating stress on mouse meibomian gland function. Ocular Surface 12(1), pp. 59-68. (10.1016/j.jtos.2013.08.002)
• Tanguay, J. S. et al. 2014. Limited stage small cell lung cancer (LS SCLC) South East Wales experience. Lung Cancer 88(Supp 1), pp. S66. (10.1016/S0169-5002(14)70180-1)
• Tornillo, G. and Cabodi, S. 2014. 3D mammary colony-forming cell assay. Bio-Protocol 4(7)
• Vedam-Mai, V. et al. 2014. Increased precursor cell proliferation after deep brain stimulation for Parkinson's disease: a human study. PLoS ONE 9(3), article number: e88770. (10.1371/journal.pone.0088770)

2013

• Anjos-Afonso, F., Currie, E., Palmer, H., Foster, K., Taussig, D. and Bonnet, D. 2013. CD34− cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures. Cell Stem Cell 13(2), pp. 161-174. (10.1016/j.stem.2013.05.025)
• Bhatti, H., Basra, M. and Patel, G. K. 2013. Hair restoration approaches for early onset male androgenetic alopecia. Journal of Cosmetic Dermatology 12(3), pp. 223-231. (10.1111/jocd.12047)
• Cater, M. A. et al. 2013. Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology 8(7), pp. 1621-1631. (10.1021/cb400198p)
• Colmont, C. S., Ben Ketah, A., Errington, R. J., Reed, S. H., Udey, M. C. and Patel, G. K. 2013. Human basal cell carcinoma tumor-initiating cells are resistant to etoposide [Letter]. Journal of Investigative Dermatology 134(3), pp. 867-870. (10.1038/jid.2013.377)
• Colmont, C. S. et al. 2013. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proceedings of the National Academy of Sciences of the United States of America 110(4), pp. 1434-1439. (10.1073/pnas.1211655110)
• Daly, C. S. 2013. The roles of the APC proteins in homeostasis and tumourigenesis. PhD Thesis, Cardiff University.
• Eccles, S. A. et al. 2013. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research 15(5), pp. R92. (10.1186/bcr3493)
• Gastaldi, S. et al. 2013. Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer. Oncogene 32, pp. 1428-1440. (10.1038/onc.2012.154)
• Guha, P., Morgan, J. W., Mostoslavsky, G., Rodrigues, N. and Boyd, A. S. 2013. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12(4), pp. 407-412. (10.1016/j.stem.2013.01.006)
• Gui, L. and Homer, H. 2013. Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes. Developmental Cell 25(1), pp. 43-54. (10.1016/j.devcel.2013.02.008)
• Hammoudi, A. et al. 2013. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications 440(3), pp. 364-370. (10.1016/j.bbrc.2013.08.076)
• Holik, A. et al. 2013. Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells 31(11), pp. 2457-2466. (10.1002/stem.1498)
• Jaganathan, B., Anjos-Afonso, F., Kumar, A. and Bonnet, D. 2013. Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche. Journal of Biomedical Science 20(1), article number: 66. (10.1186/1423-0127-20-66)
• Jarde, T. et al. 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32(7), pp. 883-893. (10.1038/onc.2012.103)
• Lloyd-Lewis, B., Fletcher, A. G., Dale, T. C. and Byrne, H. M. 2013. Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5(4), pp. 391-407. (10.1002/wsbm.1221)
• Marsh Durban, V., Davies, E. J., Williams, G. T. and Clarke, A. R. 2013. PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. The Journal of Pathology 230(2), pp. 165-173. (10.1002/path.4189)
• Marsh Durban, V., Deuker, M. M., Bosenberg, M. W., Phillips, W. and McMahon, M. 2013. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. The Journal of Clinical Investigation 123(12), pp. 5104-5118. (10.1172/JCI69619)
• Meniel, V. et al. 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9(8), article number: e1003638. (10.1371/journal.pgen.1003638)
• Miraki-Moud, F. et al. 2013. Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation. Proceedings of the National Academy of Sciences of the United States of America 110(33), pp. 13576-13581. (10.1073/pnas.1301891110)
• Parry, L., Young, M., El Marjou, F. and Clarke, A. R. 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31(4), pp. 776-785. (10.1002/stem.1326)
• Pearson, H. B. 2013. Modelling metastasis in vivo. In: Madame Curie Bioscience Database. Georgetown TX: Landes Bioscience
• Phesse, T. and Sansom, O. J. 2013. Responding to R-spondin: slit2 potentiates intestinal regeneration. Cell Stem Cell 13, pp. 512-514. (10.1016/j.stem.2013.10.006)
• Pouliot, N., Pearson, H. and Burrows, A. 2013. Investigating metastasis using in vitro platforms. In: Madame Curie Bioscience Database. Georgetown TX: Landes Bioscience
• Raja, M. 2013. Using GEMMs to investigate novel therapeutic strategies for colorectal cancer. PhD Thesis, Cardiff University.
• Regan, J. et al. 2013. Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner. Cell Reports 4(1), pp. 110-123. (10.1016/j.celrep.2013.05.044)
• Riris, S., Cawood, S., Gui, L., Serhal, P. and Homer, H. A. 2013. Immunofluorescence staining of spindles, chromosomes, and kinetochores in human oocytes. In: Homer, H. A. ed. Mammalian Oocyte Regulation: Methods and Protocols. Methods in Molecular Biology Vol. 957. New York: Humana Press, pp. 179-187., (10.1007/978-1-62703-191-2_12)
• Rodrigues, N. and Tipping, A. J. 2013. Transcription factor GATA-2 regulates quiescence of hematopoietic stem and progenitor cells. In: Hayat, M. A. ed. Tumor Dormancy, Quiescence, and Senescence, Volume 2., Vol. 2. Springer, pp. 277-288., (10.1007/978-94-007-7726-2_26)
• Rouault-Pierre, K. et al. 2013. HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress. Cell Stem Cell 13(5), pp. 549-563. (10.1016/j.stem.2013.08.011)
• Siebzehnrubl, F. et al. 2013. The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. EMBO Molecular Medicine 5(8), pp. 1196-1212. (10.1002/emmm.201302827)
• Siebzehnrubl, F. and Steindler, D. A. 2013. Isolating and culturing of precursor cells from the adult human brain. In: Reynolds, B. A. and Delerolle, L. P. eds. Neural Progenitor Cells., Vol. 1059. Methods in Molecular Biology Springer, pp. 79-86., (10.1007/978-1-62703-574-3_7)
• Silver, D. J. et al. 2013. Chondroitin Sulfate Proteoglycans Potently Inhibit Invasion and Serve as a Central Organizer of the Brain Tumor Microenvironment. Journal of Neuroscience 33(39), pp. 15603-15617. (10.1523/JNEUROSCI.3004-12.2013)
• Smalley, M. J., Piggott, L. and Clarkson, R. W. E. 2013. Breast cancer stem cells: obstacles to therapy. Cancer Letters 338(1), pp. 57-62. (10.1016/j.canlet.2012.04.023)
• Trejo, C. L., Green, S., Marsh Durban, V., Collisson, E. A., Iezza, G., Phillips, W. A. and McMahon, M. 2013. Mutationally activated PIK3CAH1047R cooperates with BRAFV600E to promote lung cancer progression. Cancer Research 73(21), pp. 6448-6461. (10.1158/0008-5472.CAN-13-0681)
• Wakefield, A. M., Soukupová, J., Montagne, A., Ranger, J., French, R., Muller, W. and Clarkson, R. W. E. 2013. Bcl3 selectively promotes metastasis of ErbB2-driven mammary tumors. Cancer Research 73(2), pp. 745-755. (10.1158/0008-5472.CAN-12-1321)
• Young, M. 2013. The effects of aberrant Wnt signalling on the murine intestinal stem cell compartment. PhD Thesis, Cardiff University.
• Young, M., Ordonez, L. and Clarke, A. R. 2013. What are the best routes to effectively model human colorectal cancer?. Molecular Oncology 7(2), pp. 178-189. (10.1016/j.molonc.2013.02.006)
• Zvelebil, M. et al. 2013. Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers. Breast Cancer Research 15(2), article number: R25. (10.1186/bcr3403)

2012

• Boyd, A. S., Rodrigues, N., Lui, K. O., Fu, X. and Xu, Y. 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30(5), pp. 797-803. (10.1002/stem.1066)
• Braun, S., Humphreys, C. and Dale, T. C. 2012. Evolutionary routes from a prebiotic ANA-world. Communicative & Integrative Biology 5(2), pp. 199-202. (10.4161/cib.18892)
• Colmont, C. S., Harding, K. G., Piguet, V. and Patel, G. K. 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21(8), pp. 576-580. (10.1111/j.1600-0625.2012.01533.x)
• Feng, G. J. et al. 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143(6), pp. 1650-1659. (10.1053/j.gastro.2012.08.047)
• Gui, L. and Homer, H. 2012. Spindle assembly checkpoint signalling is uncoupled from chromosomal position in mouse oocytes. Development 139(11), pp. 1941-1946. (10.1242/dev.078352)
• Hogan, C. 2012. Impact of interactions between normal and transformed epithelial cells and the relevance to cancer. Cellular and Molecular Life Sciences 69(2), pp. 203-213. (10.1007/s00018-011-0806-3)
• Hopkins, S. et al. 2012. Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis. Developmental Cell 23(3), pp. 547-559. (10.1016/j.devcel.2012.08.001)
• Jarde, T. and Dale, T. C. 2012. Wnt signalling in murine postnatal mammary gland development. Acta Physiologica 204(1), pp. 118-127. (10.1111/j.1748-1716.2011.02283.x)
• Kallinikou, K. et al. 2012. Engraftment defect of cytokine-cultured adult human mobilized CD34+ cells is related to reduced adhesion to bone marrow niche elements. British Journal of Haematology 158(6), pp. 778-787. (10.1111/j.1365-2141.2012.09219.x)
• Khritankova, I. V., Kukharskiy, M. S., Lytkina, O. A., Bachurin, S. O. and Shorning, B. 2012. Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells. Doklady Biochemistry and Biophysics 446(1), pp. 251-253. (10.1134/S1607672912050079)
• Milani, E. S. et al. 2012. Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation. Development 140(1), pp. 117-125. (10.1242/dev.082941)
• Muñoz-Descalzo, S., De Navascues Melero, J. and Arias, A. M. 2012. Wnt-Notch signalling: An integrated mechanism regulating transitions between cell states. Bioessays 34(2), pp. 110-118. (10.1002/bies.201100102)
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• Patel, G. K., Yee, C. L., Terunuma, A., Telford, W. G., Voong, N., Yuspa, S. H. and Vogel, J. C. 2012. Identification and characterization of tumor-initiating cells in human primary cutaneous squamous cell carcinoma. Journal of Investigative Dermatology 132(2), pp. 401-409. (10.1038/jid.2011.317)
• Patel, G. K., Yee, C. L., Yuspa, S. H. and Vogel, J. C. 2012. A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice. Journal of Investigative Dermatology 132(2), pp. 284-290. (10.1038/jid.2011.284)
• Reed, K. R., Tunster, S. J., Young, M., Carrico, A. S., John, R. M. and Clarke, A. R. 2012. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut 61(10), pp. 1435-1438. (10.1136/gutjnl-2011-300842)
• Regan, J. L., Kendrick, H., Magnay, F., Vafaizadeh, V., Groner, B. and Smalley, M. 2012. c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer. Oncogene 31(7), pp. 869-883. (10.1038/onc.2011.289)
• Rodrigues, N., Tipping, A. J., Wang, Z. and Enver, T. 2012. GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. The International Journal of Biochemistry & Cell Biology 44(3), pp. 457-460. (10.1016/j.biocel.2011.12.004)
• Shorning, B. et al. 2012. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut 61(2), pp. 202-213. (10.1136/gutjnl-2011-300046)
• Smalley, M. J. et al. 2012. Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods. Journal of Mammary Gland Biology and Neoplasia 17(2), pp. 91-97. (10.1007/s10911-012-9257-1)
• Smartt, H. J. M. et al. 2012. β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61(9), pp. 1306-1314. (10.1136/gutjnl-2011-300817)
• Soady, K. and Smalley, M. J. 2012. Slugging their way to immortality: Driving mammary epithelial cells into a stem cell-like state. Breast Cancer Research 14(5), article number: 319. (10.1186/bcr3188)
• Soukupova, J., Brancale, A., Westwell, A. D. and Clarkson, R. W. E. 2012. Inhibitors of Bcl-3 as a novel therapeutic strategy for HER2+ breast cancer. European Journal of Cancer 48(5), pp. S225-S225.
• Wang, S. et al. 2012. Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain Research 1464, pp. 61-72. (10.1016/j.brainres.2012.04.039)
• Williams, R., Shorning, B., Datta, S., Kynaston, H. and Clarke, A. R. 2012. Development and characterisation of a bladder cancer model [Poster]. BJU International 109(S7), pp. 25-25. (10.1111/j.1464-410X.2012.11177.x)

2011

• Anjos-Afonso, F. and Bonnet, D. 2011. Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells. Best Practice & Research Clinical Haematology 24(1), pp. 13-24. (10.1016/j.beha.2010.11.003)
• Annakesavan, A., Patel, G. K. and Harding, K. G. 2011. Recurrence of diffuse large B cell lymphoma presenting as a chronic non healing wound - case report [Abstract]. Wound Repair and Regeneration 19(2), pp. A10. (10.1111/j.1524-475X.2010.00670.x)
• Bosanquet, D. C., Davies, W. L., May, K., Harding, K. G. and Patel, G. K. 2011. Acute generalised exanthematous pustulosis following intravitreal Ranibizumab. International Wound Journal 8(3), pp. 317-319. (10.1111/j.1742-481X.2011.00799.x)
• Braun, S., Humphreys, C., Fraser, E., Brancale, A., Bochtler, M. and Dale, T. C. 2011. Amyloid-Associated Nucleic Acid Hybridisation. PLoS ONE 6(5), article number: e19125. (10.1371/journal.pone.0019125)
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• Miyamoto, T. et al. 2011. Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates. Human Molecular Genetics 20(10), pp. 2058-2070. (10.1093/hmg/ddr090)
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• Parry, L. and Clarke, A. R. 2011. The roles of the methyl-CpG binding proteins in cancer. Genes & Cancer 2(6), pp. 618-630. (10.1177/1947601911418499)
• Pearson, H. B. et al. 2011. SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. The Journal of Clinical Investigation 121(11), pp. 4257-4267. (10.1172/JCI58509)
• Perrins, R. D. et al. 2011. Doing more with less: a method for low total mass, affinity measurement using variable-length nanotethers. Analytical Chemistry 83(23), pp. 8900-8905. (10.1021/ac2012569)
• Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
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• Richards, A. J., Hagelstein, S. M., Patel, G. K., Ivins, N. M., Sweetland, H. M. and Harding, K. G. 2011. Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess. International Wound Journal 8(6), pp. 608-611. (10.1111/j.1742-481X.2011.00838.x)
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2010

• Ashton, G. H. et al. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell 19(2), pp. 259-269. (10.1016/j.devcel.2010.07.015)
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• De Navascues Melero, J. and Modolell, J. 2010. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development 127(9-12), pp. 393-406. (10.1016/j.mod.2010.05.001)
• Evers, B. et al. 2010. A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis. Journal of Pathology 220(1), pp. 34-44. (10.1002/path.2655)
• Ewan, K. B. R. et al. 2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70(14), pp. 5963-5973. (10.1158/0008-5472.CAN-10-1028)
• Ghafoor, S. Z. . A., MacRae, E. A., Harding, K. G. and Patel, G. K. 2010. Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. International Wound Journal 7(5), pp. 418-422. (10.1111/j.1742-481X.2010.00697.x)
• Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18(6), pp. 594-604. (10.1111/j.1524-475X.2010.00630.x)
• Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
• Kajita, M. et al. 2010. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. Journal of Cell Science 123(2), pp. 171-180. (10.1242/jcs.057976)
• Minhas, U., Sanders, A. J., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair and Regeneration 18(6), pp. A89. (10.1111/j.1524-475X.2010.00633.x)
• Molyneux, G. et al. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3), pp. 403-417. (10.1016/j.stem.2010.07.010)
• Patel, G. K. and Harding, K. G. 2010. Nicorandil ulcer: moves beyond the mucosa. Annals of the Royal College of Surgeons of England 92(6), pp. 451-452. (10.1308/003588410X12699663905195)
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• Rangaraj, A., Ye, L., Patel, G. K., Price, P. E., Harding, K. G. and Jiang, W. G. 2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
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2009

• Alexander, C. M. et al. 2009. Separating stem cells by flow cytometry: reducing variability for solid tissues. Cell Stem Cell 5(6), pp. 579-583. (10.1016/j.stem.2009.11.008)
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• Kasry, A., Borri, P., Davies, P. R., Harwood, A. J., Thomas, N., Lofas, S. and Dale, T. C. 2009. Comparison of methods for generating planar DNA-modified surfaces for hybridization studies. ACS Applied Materials & Interfaces 1(8), pp. 1793-1798. (10.1021/am9003073)
• Kranc, K. R. et al. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6), pp. 659-665. (10.1016/j.stem.2009.11.001)
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• Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H. and Meehan, R. R. 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136(13), pp. 2277-2286. (10.1242/dev.032227)
• Shorning, B. et al. 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4(1), article number: e4264. (10.1371/journal.pone.0004264)
• Siebzehnrubl, F. et al. 2009. Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells. Brain Pathology 19(3), pp. 399-408. (10.1111/j.1750-3639.2008.00189.x)
• Smith, P. J., Furon, E., Wiltshire, M., Campbell, L., Feeney, G. P., Snyder, R. D. and Errington, R. J. 2009. ABCG2-Associated Resistance to Hoechst 33342 and Topotecan in a Murine Cell Model with Constitutive Expression of Side Population Characteristics. Cytometry Part A 75A(11), pp. 924-933. (10.1002/cyto.a.20800)
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2008

• Anjos-Afonso, F. and Bonnet, D. 2008. Isolation, culture, and differentiation potential of mouse marrow stromal cells. Current Protocols in Stem Cell Biology (10.1002/9780470151808.sc02b03s7)
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• Freeman, J., Zollo, M. and Dale, T. C. 2008. Investigating h-Prune activation of Wnt signalling in breast cancer. Breast Cancer Research 10(s2), pp. 10. (10.1186/bcr1899)
• Huttner, H. B. et al. 2008. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells 26(3), pp. 698-705. (10.1634/stemcells.2007-0639)
• Kadri, H., Dale, T. C., Ewan, K. B. R. and Westwell, A. 2008. The design, synthesis and antitumour evaluation of novel small molecule inhibitors of the Dishevelled PDZ domain [Poster Presentation/Abstract]. EJC Supplements 6(12), pp. 137., article number: 436. (10.1016/S1359-6349(08)72370-X)
• Kendrick, H., Regan, J., Magnay, F., Grigoriadis, A., Mitsopoulos, C., Zvelebil, M. and Smalley, M. J. 2008. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 9(1), article number: 591. (10.1186/1471-2164-9-591)
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• Marsh Durban, V., Winton, D. J., Williams, G. T., Dubois, N., Trumpp, A., Sansom, O. J. and Clarke, A. R. 2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40(12), pp. 1436-1444. (10.1038/ng.256)
• Melchor, L. and Smalley, M. J. 2008. Highway to heaven: mammary gland development and differentiation. Breast Cancer Research 10(5), pp. 305-307. (10.1186/bcr2147)
• Pálmer, H. G., Anjos-Afonso, F., Carmeliet, G., Takeda, H. and Watt, F. M. 2008. The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. PLoS ONE 3(1), article number: e1483. (10.1371/journal.pone.0001483)
• Pearson, H. B. 2008. Development and characterisation of novel mouse models of human prostate cancer. PhD Thesis, Cardiff University.
• Pearson, H. B., McCarthy, A., Collins, C. M., Ashworth, A. and Clarke, A. R. 2008. Lkb1 defiency causes prostate neoplasia in the mouse. Cancer Research 68(7), pp. 2223-2232. (10.1158/0008-5472.CAN-07-5169)
• Phesse, T., Parry, L., Reed, K. R., Ewan, K. B. R., Dale, T. C., Sansom, O. J. and Clarke, A. R. 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28(19), pp. 6094-6103. (10.1128/MCB.00539-08)
• Reed, K. R. et al. 2008. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 105(48), pp. 18919-18923. (10.1073/pnas.0805778105)
• Reed, K. R., Meniel, V., Marsh Durban, V., Cole, A., Sansom, O. J. and Clarke, A. R. 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8, article number: 162. (10.1186/1471-2407-8-162)
• Rodrigues, N. et al. 2008. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood 112(13), pp. 4862-4873. (10.1182/blood-2008-01-136564)
• Siebzehnrubl, F. and Blumcke, I. 2008. Neurogenesis in the human hippocampus and its relevance to temporal lobe epilepsies. Epilepsia 49(s5), pp. 55-65. (10.1111/j.1528-1167.2008.01638.x)
• Smalley, M. J., Reis-Filho, J. and Ashworth, A. 2008. BRCA1 and stem cells: tumour typecasting. Nature Cell Biology 10(4), pp. 377-379. (10.1038/ncb0408-377)
• Taussig, D. C. et al. 2008. Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood -New York- 112(3), pp. 568-575. (10.1182/blood-2007-10-118331)
• Tiffen, P., Omidvar, N., Marquez, N., Croston, D., Watson, C. and Clarkson, R. W. E. 2008. A dual role for Oncostatin M signalling in the differentiation and death of mammary epithelial cells in vivo. Molecular Endocrinology 22(12), pp. 2677-2688. (10.1210/me.2008-0097)
• Wakefield, A., Piggott, L., Croston, D., Jiang, W. G. and Clarkson, R. W. E. 2008. Suppression of the NF-kappa B cofactor Bcl3 inhibits mammary epithelial cell apoptosis and, in breast tumours, correlates with poor prognosis. Breast Cancer Research 10(S2), article number: O4. (10.1186/bcr1884)

2007

• Anjos-Afonso, F. and Bonnet, D. 2007. Flexible and dynamic organization of bone marrow stromal compartment. British Journal of Haematology 139(3), pp. 373-384. (10.1111/j.1365-2141.2007.06827.x)
• Britt, K., Ashworth, A. and Smalley, M. J. 2007. Pregnancy and the risk of breast cancer. Endocrine-Related Cancer 14(4), pp. 907-933. (10.1677/ERC-07-0137)
• Buslei, R. et al. 2007. Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas. Acta Neuropathologica 113(5), pp. 585-590.
• Clarke, A. R. and Meniel, V. 2007. The intestinal stem cell niche studied through conditional transgenesis. Presented at: The Cancer Stem Cell Workshop, Berlin, Germany, November 15- 17 2006 Presented at Wiestler, O. D., Haendler, B. and Mumberg, D. eds.Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy, Vol. 2006/5. Ernst Schering Foundation Symposium Proceedings Berlin: Springer pp. 99-108., (10.1007/2789_2007_046)
• Coras, R. et al. 2007. The peroxisome proliferator-activated receptor-gamma agonist troglitazone inhibits transforming growth factor-beta-mediated glioma cell migration and brain invasion. Molecular Cancer Therapeutics 6(6), pp. 1745-1754. (10.1158/1535-7163.MCT-06-0763)
• De Navascues Melero, J. and Modolell, J. 2007. tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification. Development 134(9), pp. 1779-1788. (10.1242/dev.02844)
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• Dupre-Crochet, S. et al. 2007. Casein Kinase 1 Is a novel negative regulator of E-cadherin-based cell-cell contacts. Molecular and Cellular Biology 27(10), pp. 3804-3816. (10.1128/MCB.01590-06)
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• Hosking, C. R. et al. 2007. The transcriptional repressor Glis2 Is a novel binding partner for p120 catenin. Molecular biology of the cell 18(5), pp. 1918-1927. (10.1091/mbc.E06-10-0941)
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• Matthews, J., Watson, S. M. R., Tevendale, M. C. L., Watson, C. J. and Clarke, A. R. 2007. Caspase-dependent proteolytic cleavage of STAT3a in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines. BMC Cancer 7(29), pp. 1-12. (10.1186/1471-2407-7-29)
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2006

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2005

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2004

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2003

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2002

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2001

• Cheng, T., Shen, H., Rodrigues, N., Stier, S. and Scadden, D. T. 2001. Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1. Blood 98(13), pp. 3643-3649. (10.1182/blood.V98.13.3643)
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2000

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• Gordon, K. et al. 2000. A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland. Breast Cancer Research 2, pp. 222-235. (10.1186/bcr57)
• MacKenzie, A., Payne, C., Boyle, S., Clarke, A. R. and Quinn, J. P. 2000. The human preprotachykinin-A gene promoter has been highly conserved and can drive human-like marker gene expression in the adult mouse CNS. Molecular and Cellular Neuroscience 16(5), pp. 620-630. (10.1006/mcne.2000.0902)
• Naylor, S., Smalley, M. J., Robertson, D., Gusterson, B. A., Edwards, P. A. and Dale, T. C. 2000. Retroviral expression of Wnt-1 and Wnt-7b produces different effects in mouse mammary epithelium. Journal of Cell Science 113(12), pp. 2129-2138.
• Nunez, F., Chipchase, M. D., Clarke, A. R. and Melton, D. W. 2000. Nucleotide excision repair gene (ERCC1) deficiency causes G2 arrest in hepatocytes and a reduction in liver binucleation: The role of p53 and p21. Faseb Journal 14(9), pp. 1073-1082.
• Parry, L., Maynard, J. H., Patel, A., Hodges, A., von Deimling, A., Sampson, J. R. and Cheadle, J. P. 2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Human Genetics 107(4), pp. 350-356. (10.1007/s004390000390)
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• Sarkar, L., Cobourne, M., Naylor, S., Smalley, M. J., Dale, T. C. and Sharpe, P. T. 2000. Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proceedings of the National Academy of Sciences of the United States of America 97(9), pp. 4520-4524. (10.1073/pnas.97.9.4520)
• Toft, N. J. et al. 2000. In vivo administration of O6-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine. Carcinogenesis 21(4), pp. 593-598.
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1999

• Feng, G., Goodridge, H. S., Harnett, M. M., Wei, X. Q., Nikolaev, A. V., Higson, A. P. and Liew, F. -. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. Journal of Immunolgy 163(12), pp. 6403-6412.
• Smalley, M. J. and Dale, T. C. 1999. Wnt signalling in mammalian development and cancer. Cancer and Metastasis Reviews 18(2), pp. 215-230. (10.1023/A:1006369223282)
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• Smalley, M. J. et al. 1999. Behavior of a cell line derived from normal human hepatocytes on non-physiological and physiological-type substrates: Evidence for enhancement of secretion of liver-specific proteins by a three-dimensional growth pattern. In Vitro Cellular and Developmental Biology - Animal 35(1), pp. 22-32. (10.1007/s11626-999-0040-6)
• Smalley, M. J., Titley, J., Paterson, H., Perusinghe, N., Clarke, C. and O'Hare, M. J. 1999. Differentiation of separated mouse mammary luminal epithelial and myoepithelial cells cultured on EHS matrix analyzed by indirect immunofluorescence of cytoskeletal antigens. Journal of Histochemistry & Cytochemistry 47(12), pp. 1513-1524. (10.1177/002215549904701203)

1998

• McInnes, I. B., Leung, B. P., Feng, G., Sturrock, R. D., Field, M. and Foo, Y. L. 1998. Reply to - a role for IL-15 in rheumatoid arthritis?. Nature Medicine 4, pp. 643-643. (10.1038/nm0698-643b)
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1997

• Dixon, P., Feist, S., Kehoe, E., Parry, L., Stone, D. and Way, K. 1997. Isolation of viral haemorrhagic septicaemia virus from Atlantic herring Clupea harengus from the Atlantic herring Clupea harengus from the English channel. Diseases of Aquatic Organisms 30(2), pp. 81-89.
• Parry, L. and Dixon, P. F. 1997. Stability of nine viral haemorrhagic septicaemia virus (VHSV) isolates in seawater. Bulletin of the European Association of Fish Pathologists 17(1), pp. 31-36.

1996

• Huang, F. P., Feng, G. J., Lindop, G., Stott, D. I. and Liew, F. W. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice. Journal of Experimental Medicine 183(4), pp. 1447-1459. (10.1084/jem.183.4.1447)

1990

• Millar, J. B., McGowan, C. H., Lenaers, G., Jones, R. and Russell, P. 1990. p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast. Embo Journal 10(13), pp. 5610-5621.

1989

• Jones, R. and Jones, N. C. 1989. Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian transcription factor ATF. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 86(7), pp. 2176-2180.

1988

• Jones, R., Moreno, S., Nurse, P. and Jones, N. C. 1988. Expression of the SV40 promoter in fission yeast: identification and characterization of an AP-1-like factor. Cell 53(4), pp. 659-667. (10.1016/0092-8674(88)90581-8)

1985

• Zhao, D., Feng, G., Wu, X. and Zuo, Q. 1985. Seizures induced by intraventricular microinjection of ionised cobalt in the rat -- a new experimental model of epilepsy. Brain Research 342(2), pp. 323-329. (10.1016/0006-8993(85)91132-1)